<scp>C‐R</scp>eactive protein and soluble intracellular adhesion molecule‐1 are related to pulse wave reflection in type 1 diabetes 在1型糖尿病中<scp>C</scp>‐反应蛋白以及可溶性细胞间黏附分子在1与脉冲波反射有关

Rogowicz-Frontczak, Anita; Piłaciński, Stanisław; Araszkiewicz, Aleksandra; Zozulińska−Ziółkiewicz, Dorota; Wykretowicz, Andrzej; Wierusz‐Wysocka, Bogna

doi:10.1111/1753-0407.12129

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…Various studies investigated associations between circulating MMP-1 [ 45 ], MMP-2 [ 46 , 47 ], MMP-3 [ 45 ], MMP-9 [ 46 – 49 ]. MMP-10 [ 45 ], and TIMP-1 [ 46 ] with other markers of arterial stiffness in both type 1 [ 48 ] and type 2 [ 45 – 47 , 49 ] diabetic individuals, but did not find significant associations.…”

Section: Discussionmentioning

confidence: 99%

Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Peeters

Engelen

Buijs

et al. 2017

Cardiovasc Diabetol

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BackgroundAltered regulation of extracellular matrix (ECM) composition by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase (TIMPs) may contribute to arterial stiffening. We investigated associations between circulating MMP-1, -2, -3, -9, -10 and TIMP-1, and carotid-femoral pulse wave velocity (cfPWV) and pulse pressure (PP), as markers of arterial stiffness in type 1 diabetic patients.MethodsIndividuals with type 1 diabetes from three different cohorts were included in this study: EURODIAB Prospective Complications study (n = 509), LEACE (n = 370) and PROFIL (n = 638). Linear regression analyses were used to investigate cross-sectional associations between circulating levels of MMP-1, -2, -3, -9, -10, and TIMP-1 and cfPWV (n = 614) as well as office PP (n = 1517). Data on 24-h brachial and 24-h central PP were available in 638 individuals from PROFIL. Analyses were adjusted for age, sex, duration of diabetes, HbA1c, mean arterial pressure (MAP), and eGFR, and additionally for other cardiovascular risk factors and presence of vascular complications.ResultsAfter adjustment for potential confounders and presence of vascular complications, circulating MMP-3 was associated with cfPWV [β per 1 SD higher lnMMP3 0.29 m/s (0.02; 0.55)]. In addition, brachial and central 24-h PP measurements in PROFIL were significantly associated with MMP-2 [(1.40 (0.47:2.33) and 1.43 (0.63:2.23)]. Pooled data analysis showed significant associations of circulating levels of MMP-1 and MMP-2 with office PP [β per 1 SD higher lnMMP-1 and lnMMP-2 = − 0.83 mmHg (95% CI − 1.50; − 0.16) and = 1.33 mmHg (0.55; 2.10), respectively].ConclusionsMMPs-1, -2, and -3 are independently associated with markers of arterial stiffening in patients with type 1 diabetes and may become therapeutic targets.Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-017-0620-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Peeters

Engelen

Buijs

et al. 2017

Cardiovasc Diabetol

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“…In the numerous studies on the pathogenesis of diabetic retinopathy more and more attention is paid to inflammatory and angiogenic factors [ 7 , 8 , 61 - 63 ]. The development and progression of diabetic retinopathy may result on one hand from stimulation of immune cells in metabolically uncontrolled disease and on the other hand from the presence of proinflammatory cytokines, which reflects the ongoing immune processes initiated already in the phase of prediabetes.…”

Section: Neuroinflammation In the Course Of Diabetesmentioning

confidence: 99%

Neurodegeneration and Neuroinflammation in Diabetic Retinopathy: Potential Approaches to Delay Neuronal Loss

Kadłubowska¹,

Malaguarnera²,

Wąż³

et al. 2016

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In spite of the extensive research the complex pathogenesis of diabetic retinopathy (DR) has not been fully elucidated. For many years it has been thought that diabetic retinopathy manifests only with microangiopathic lesions, which are totally responsible for the loss of vision in diabetic patients. In view of the current knowledge on the microangiopathic changes in the fundus of the eye, diabetic retinopathy is perceived as a neurodegenerative disease. Several clinical tools are available to detect neuronal dysfunction at early stages of diabetes. Many functional changes in the retina can be identified before vascular pathology develops, suggesting that they result from a direct effect of diabetes on the neural retina. In the course of diabetes there is a chronic loss of retinal neurons due to increased frequency of apoptosis. The neuronal apoptosis begins very early in the course of diabetes. This observation has led to suggestions that precautions against DR should be implemented immediately after diabetes is diagnosed. Neurodegeneration cannot be reversed; therefore treatments preventing neuronal cell loss in the retina need to be developed to protect diabetic patients. This review is an attempt to summarize what is currently known about the mechanisms of neuronal apoptosis in the context of diabetic retinopathy and vascular degeneration as well as about potential treatments of DR

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HDL functionality in type 1 diabetes

et al. 2017

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C‐Reactive protein and soluble intracellular adhesion molecule‐1 are related to pulse wave reflection in type 1 diabetes 在1型糖尿病中C‐反应蛋白以及可溶性细胞间黏附分子在1与脉冲波反射有关

Abstract: In T1D parameters of wave reflection are related to markers of inflammation.

Cited by 3 publications

References 57 publications

Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Circulating matrix metalloproteinases are associated with arterial stiffness in patients with type 1 diabetes: pooled analysis of three cohort studies

Neurodegeneration and Neuroinflammation in Diabetic Retinopathy: Potential Approaches to Delay Neuronal Loss

HDL functionality in type 1 diabetes

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