<scp>CD</scp>89 (<scp>Fc</scp>α<scp>RI</scp>)

Spriel, Annemiek B. van; Winkel, Jan G. J. van de

doi:10.1002/0471203076.emm0354

Wiley Encyclopedia of Molecular Medicine 2002

DOI: 10.1002/0471203076.emm0354

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CD89 (FcαRI)

Annemiek B. van Spriel¹,

Jan G. J. van de Winkel²

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2002

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Mac-1 (CD11b/CD18) as Accessory Molecule for FcαR (CD89) Binding of IgA

Spriel¹,

Leusen

Vilé

et al. 2002

The Journal of Immunology

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IgA, the principal ligand for FcαRI, exists in serum as monomeric IgA and at mucosal sites as secretory IgA (SIgA). SIgA consists of dimeric IgA linked by joining chain and secretory components. Human polymorphonuclear leukocytes (PMN) and mouse PMN transgenic for human FcαRI exhibited spreading and elicited respiratory burst activity upon interaction with either serum or SIgA. However, PMN devoid of the β2 integrin Mac-1 (Mac-1−/−) were unable to bind SIgA, despite expression of FcαRI. Consistent with this, serum IgA stimulated Mac-1−/− PMN oxygen radical production, in contrast to SIgA. Binding studies showed the secretory component, by itself, to interact with Mac-1-expressing PMN, but not with Mac-1−/− PMN. These data demonstrate an essential role for Mac-1 in establishing SIgA-FcαRI interactions.

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Mac-1 (CD11b/CD18) as Accessory Molecule for FcαR (CD89) Binding of IgA

Spriel¹,

Leusen

Vilé

et al. 2002

The Journal of Immunology

Self Cite

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show abstract

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CD89 (FcαRI)

Cited by 1 publication

References 23 publications

Mac-1 (CD11b/CD18) as Accessory Molecule for FcαR (CD89) Binding of IgA

Mac-1 (CD11b/CD18) as Accessory Molecule for FcαR (CD89) Binding of IgA

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