<scp>CD25</scp>: A potential tumor therapeutic target

Peng, Yujia; Tao, Yiran; Zhang, Ya; Wang, Jiaxing; Yang, Jinliang; Wang, Yuxi

doi:10.1002/ijc.34281

Cited by 40 publications

(22 citation statements)

References 114 publications

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“…CD25 is the α-chain of the heterotrimer IL-2 receptor and highly expressed in regulatory T cells(Treg) [40]. In the tumor microenvironment, in ltration of Tregs can cause an imbalance of effector T cells (Teffs) and Tregs, which are associated with the progression of cancer [41]. GM can play an important role in immune response [42].Herein, we demonstrated that CD25 on resting Treg may be a critical moderator between PWY-5989 and LUAD.…”

Section: Discussionmentioning

confidence: 99%

Role of CD25 on resting Treg immune cell in Mediating the Effect of stearate biosynthesis microbiome pathway on lung adenocarcinoma

Yang,

Li,

Liu

et al. 2024

Preprint

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Background Gut microbiota (GM) often influences the development of diseases by regulating the immune system. The causal relationship between GM and lung adenocarcinoma (LUAD) and whether it can be mediated by immune cells remains unclear. Methods We conducted two-step, two-sample Mendelian randomization (MR) analyses. The data of GM, LUAD and immune cells for analysis were derived from publicly available genetic data. The causal relationship between GM and LUAD, as well as the mediation effect of immune cells in the association between GM and LUAD were estimated using inverse variance weighted (IVW), MR-Egger and weighted median. Sensitivity analyses were implemented with Cochran's Q test, MR-Egger intercept test, MR-PRESSO. Results MR analyses determined the protective effects of PWY-5989 (stearate biosynthesis II bacteria and plants) on LUAD. In addition, CD25 on resting Treg was negatively correlated with LUAD. Of note, the mediation MR illustrated that in the presence of CD25 on resting Treg, PWY-5989 can promote the risk of LUAD by inhibiting the expression of CD25 on resting Treg. Conclusion The study suggested a causal relationship between PWY-5989 and LUAD, which may be mediated by CD25 on resting Treg.

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Section: Discussionmentioning

confidence: 99%

Role of CD25 on resting Treg immune cell in Mediating the Effect of stearate biosynthesis microbiome pathway on lung adenocarcinoma

Yang,

Li,

Liu

et al. 2024

Preprint

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“…While B cells have been shown to suppress tumor progression, they are also implicated in inducing carcinogenesis and cancer progression [19,20]. CD25 represents the alpha component of the IL-2 receptor complex, exhibiting high expression levels in numerous hematological malignancies while remaining minimally expressed in most solid tumors [21]. Mounting research indicates that CD25 could serve as a catalyst in the proliferation of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

A Mendelian randomization study of the causal relationships between immune cells and colorectal cancer

He,

Deng

2024

Preprint

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Background: The incidence of colorectal cancer (CRC) is increasing steadily. This is corroborated by increasing evidence that establishes a connection between the regulation of immunocytes and the advancement of CRC. However, the exact underlying mechanisms remain unclear. Hence, this study aimed to elucidate the link between immune cells and vulnerability to CRC through the application of Mendelian randomization (MR) analysis. Methods Existing genome-wide association studies (GWAS) have provided summary data on immune cells and CRC in European populations. The ebi-a-GCST90018808 cohort was designated the discovery cohort, while the finn-b-C3_COLORECTAL cohort was the validation cohort. Only single nucleotide polymorphisms (SNPs) that satisfied the following conditions were selected as instrumental variables (IVs): a p-value less than 1×10–5, a linkage disequilibrium coefficient (r2) less than 0.001, and a linkage disequilibrium region width of 10000 kb. The cornerstone analytical methodology used was inverse variance weighting (IVW), which was reinforced by the MR-Egger method to assess the causality of effects. Heterogeneity analysis was performed utilizing I2 and Cochran's Q tests. To assess pleiotropy, the MR-Egger method's intercept was utilized, complemented by sensitivity evaluation through a leave-one-out approach. The two datasets were combined for meta-analysis to further validate whether the two immune cell traits were consistent between the two cohorts. Results In the discovery and validation cohorts, a causal association was found between CD25 expression on unswitched memory B cells and CD25++ CD45RA- CD4 not regulatory T cell absolute count, resulting in a decreased risk of CRC. Heterogeneity analysis indicated I2 < 50% and P >0.05 according to Cochran's Q test, suggesting no heterogeneity among the IVs. The intercept obtained from the MR‒Egger analysis showed no significant difference from zero, suggesting a negligible influence of horizontal pleiotropy on the IVs. A meta-analysis was conducted to amalgamate the aggregated data from both datasets, further corroborating the influence of the two immune cell traits in mitigating CRC risk. Conclusion The results from MR analysis reveal that CD25 expression on unswitched memory B cells and CD25++ CD45RA- CD4 not regulatory T cell absolute count are intricately associated with a reduced risk of CRC.

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“…IL2RA is the alpha-chain of the IL-2 receptor and expressed on immune and non-immune cells with different proportions [30]. From the study of Elena de Dios ea al, we obtained that high expression of CD25 and CD69 and related immune checkpoints was associated with a better short and long period cardiac structure and function in patients of post ST-elevation myocardial infarction [31].…”

Section: Discussionmentioning

confidence: 99%

Predicting diagnostic immune-related gene biomarkers in the development of heart failure after acute myocardial infarction: Bioinformatics based approaches

Chen

Mei

et al. 2022

Preprint

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Objective: Post-myocardial infarction(MI) heart failure (HF) is regarded as a public health concern; however, effective biomarkers for predicting HF are still lacking. This study aimed to identy novel biomarkers for forecasting long-term HFin AMI patients. Methods: The GSE59867 dataset was downloaded from the Gene Expression Omnibus (GEO) database, and then differentially expressed genes (DEGs) were identified with the criteria of p-value<0.05 and |log2FC|>0.5. Protein-protein interaction (PPI) network was constructed by STRING software,and then Molecular Complex Detection (MCODE) plugin and CytoHubba plugin in Cytoscape software were applied to identify potential hub genes. Moreover, immune-related genes (IRGs) were downloaded from ImmPort database. The intersection between hub genes and IRGs was regarded as potential immune-related hub genes. Finally, these genes were further assessed for expression levels and predictive ability of long-term HF. Results: A total of 200 DEGs were identified between the non-HF and HF groups, including 84 upregulated genes and 116 downregulated genes. Ten hub genes, including IL1B, CD28, CXCL8, IL2RA, KLRC4-KLRK1, CXCR5, CD40LG, FOS, TIMP1, GPR29, were further screened out by STRING, MCODE and CytoHubba. Among them, seven immune-related hub genes were filtered. Finally, we found that four genes were significantly changed between the HF and non-HF patients and all showed a predictive ability of the long-term HF, including CD28, CXCR5, FOS, IL2RA. In addition, functional enrichment analysis showed immune system process was enriched in the process of HF, including lymphocyte proliferation, T cell proliferation, lymphocyte proflieration, and IL-17 signaling pathway. Conclusion:We successfully identified four immune-related hub genes that were significantly changed between the HF and non-HF patients and all showed a predictive ability of the long-term HF, which could provide novel insights for the rationale of the development of HF.

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CD25: A potential tumor therapeutic target

Cited by 40 publications

References 114 publications

Role of CD25 on resting Treg immune cell in Mediating the Effect of stearate biosynthesis microbiome pathway on lung adenocarcinoma

Role of CD25 on resting Treg immune cell in Mediating the Effect of stearate biosynthesis microbiome pathway on lung adenocarcinoma

A Mendelian randomization study of the causal relationships between immune cells and colorectal cancer

Predicting diagnostic immune-related gene biomarkers in the development of heart failure after acute myocardial infarction: Bioinformatics based approaches

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