CD74+ fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloids
Jingheng Zhang,
Shuyao Li,
Chunmei Kuang
et al.
Abstract:The healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic scars, or even keloids in predisposed individuals. Keloids are fibro‐proliferative scar tissues that extend beyond the initial wound boundary, consisting of the actively progressing periphery and the quiescent center. The stretch‐associated outgrowth and enhanced angiogenesis are two features of the periphery of keloids. However, which cell population is responsib… Show more
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