<scp>CD99</scp> expression in Merkel cell carcinoma: a case series with an unusual paranuclear dot‐like staining pattern

Rajagopalan, Ashwyn; Browning, Debra; Salama, Samih

doi:10.1111/cup.12049

Cited by 19 publications

(15 citation statements)

References 31 publications

(49 reference statements)

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“…18,19 In this study, although Case 2 showed typical paranuclear dot-like expression of neurofilament and CD99, no positive immunoreactivity for these markers was observed in Case 1. In addition, p63 expression has been reported to be a prognostic factor in MCC cases, but MCPyV status did not correlate with survival.…”

Section: Discussioncontrasting

confidence: 48%

Merkel cell carcinoma concurrent with Bowen's disease: two cases, one with an unusual immunophenotype

Ishida

Okabe

2013

J Cutan Pathol

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The concurrence of Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC) is well known, and MCC concurrent with Bowen's disease has also been documented. Herein, we describe two cases of MCC concurrent with Bowen's disease, and one case exhibited an unusual immunophenotype. An 86-year-old male (Patient 1) and an 87-year-old female (Patient 2) presented with nodules of the chest and cheek, respectively. Histopathologic study revealed Bowen's disease and a proliferation of small round cells in the dermis and/or subcutis. Immunohistochemically, the round cells expressed endocrine markers. 'Dot' immunopositivity for cytokeratin (CK) (AE1/AE3) was observed in both patients. However, dot-like CK20 positivity was present only in the second tumor, and thyroid transcription factor-1 (TTF-1) was only positive in the first. Both cases were negative for Merkel cell polyomavirus (MCPyV). MCC concurrent with SCC usually does not involve detectable MCPyV infection, which suggests that combined MCC may develop through different tumorigenetic pathways, such as chronic ultraviolet exposure, as compared to pure MCC. Additionally, concurrent tumors may exhibit an unusual immunophenotype, such as TTF-1(+) /CK20((-)) .

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Section: Discussioncontrasting

confidence: 48%

Merkel cell carcinoma concurrent with Bowen's disease: two cases, one with an unusual immunophenotype

Ishida

Okabe

2013

J Cutan Pathol

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“…Therefore, its usefulness in the differential diagnosis of vascular tumours, in particular with angiosarcomas, may be limited. Besides a cytoplasmic and membrane expression pattern, which has already been reported in vascular tumours, in the present case we also observed the cytoplasmic, macrogranular, dot‐like pattern that has been recently reported in both benign and malign tumours of varied types . The perinuclear location of this expression pattern suggests endoplasmic reticulum‐type rather than Golgi‐type expression.…”

supporting

confidence: 87%

“…Sir : A CD99 (p30/p32mic2) cell adhesion glycoprotein intracytoplasmic dot‐like expression pattern has been reported in several tumour types, such as ependymomas, ependymoma‐like pituicytomas, the PNET component of endometrial carcinomas, anaplastic T‐cell lymphomas, pancreatic solid papillary tumours, colon adenomas and adenocarcinomas, Merkel cell carcinomas, lung small‐cell carcinomas, and, more recently, malignant soft tissue tumours such as rhabdomyosarcomas . Here, we report a similar pattern in a benign soft tissue vascular tumour, a nasal lobular capillary haemangioma (LCH).…”

supporting

confidence: 50%

“…Besides a cytoplasmic and membrane expression pattern, which has already been reported in vascular tumours, in the present case we also observed the cytoplasmic, macrogranular, dot-like pattern that has been recently reported in both benign and malign tumours of varied types. 1,2 The perinuclear location of this expression pattern suggests endoplasmic reticulumtype rather than Golgi-type expression. Whether this specific intracellular expression pattern reflects active CD99 synthesis processing warrants further investigation.…”

mentioning

confidence: 96%

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CD99 expression in nasal lobular capillary haemangioma

Elmageed

Gouhier²

2014

Histopathology

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“…In our case, the tumor calls showed positive reactivity for CD56 and MIC2, but not for CK20, chromogranin A, synaptophysin and NSE. These results favored the diagnosis of ES but were not sufficient to exclude the possibility of Merkel cell carcinoma . Recent reports have suggested that CD56 may be beneficial as it expressed in ES and Merkel cell carcinoma.…”

Section: Discussionmentioning

confidence: 93%

Application of electron microscopic analysis and fluorescent in situ hybridization technique for the successful diagnosis of extraskeletal Ewing's sarcoma

Funakoshi

Sato

Hosokawa

et al. 2015

The Journal of Dermatology

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The diagnosis of soft tissue tumors is often challenging. Immunohistochemical investigation, let alone routine histopathological investigation, may not allow definitive diagnosis in some cases. To overcome such difficulties, more advanced techniques need to be adopted. Herein, we report an extremely rare 56-year-old Japanese female case of extraskeletal Ewing's sarcoma (ES), successfully diagnosed by electron microscopy (EM) using formalin-fixed sections and fluorescence in situ hybridization (FISH). The patient had a 2-year history of a tumor growing on the leg. In routine histopathology, invasive proliferation of tumor cells was observed in the dermis. Tumor cells were round and uniform with large hyperchromatic nuclei, which were positively stained for CD56, VS38c, Ki-67, MIC2 and vimentin, but not for pan-keratin AE1 + AE3, cytokeratin 20, chromogranin A, synaptophysin and neuron-specific enolase. As these findings were not conclusive to make the final diagnosis, EM specimens were prepared from formalin-fixed sections and subjected to investigation. Cell surface projections and dense core granules were detected, suggestive of either Merkel cell carcinoma or extraskeletal ES. Subsequent FISH analysis identified reciprocal translocation of the ESWR1 gene, enabling the final diagnosis of extraskeletal ES. This study provides useful information enabling the diagnosis of this uncommon soft tissue tumor.

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CD99 expression in Merkel cell carcinoma: a case series with an unusual paranuclear dot‐like staining pattern

Cited by 19 publications

References 31 publications

Merkel cell carcinoma concurrent with Bowen's disease: two cases, one with an unusual immunophenotype

Merkel cell carcinoma concurrent with Bowen's disease: two cases, one with an unusual immunophenotype

CD99 expression in nasal lobular capillary haemangioma

Application of electron microscopic analysis and fluorescent in situ hybridization technique for the successful diagnosis of extraskeletal Ewing's sarcoma

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