<scp>CircAGK</scp> regulates high dihydrotestosterone‐induced apoptosis in <scp>DPCs</scp> through the <scp>miR‐3180‐5p/BAX</scp> axis

Wei, Hanxiao; Yang, Shuai; Yi, Tian; Xu, Xiaoyu; Liu, Chang; Shen, Caiqi; Guo, Yanping; Li, Qiang; Jin, Peisheng

doi:10.1096/fj.202200849r

Cited by 5 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wei et al found that circ_0002980 promotes dermal papilla cell apoptosis through the miR-3180-5p/BAX signaling axis. This axis mediates androgenic alopecia (AGA), providing novel targets and ideas for AGA [ 35 ]. In this study, miR-1303 was identified as a possible target miRNA of circ_0002980 using bioinformatics prediction.…”

Section: Discussionmentioning

confidence: 99%

hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Wang,

Li,

et al. 2023

Aging

View full text Add to dashboard Cite

Background: Liver cancer (LC) is a rare malignancy. Circular RNA (circRNA) dysregulation is associated with LC metastasis. hsa_circ_0002980 was found to be unexpectedly downregulated in LC tissues; however, its specific function remains unclear. Methods: hsa_circ_0002980 expression was confirmed using RT-qPCR. The effects of circ_0002980 on the proliferation, metastasis, and EMT-related proteins of LC cells were assessed using clone formation, flow cytometry, Transwell assays, and Western blotting. The relationship between circ_0002980 and miR-1303 or miR-1303 and CADM2 was analyzed using a dual-luciferase reporter assay. Thereafter, the influence of these three genes on LC cell progression was determined through rescue experiments. Results: hsa_circ_0002980 expression was lower in LC. circ_0002980 overexpression inhibited the proliferation, migration, invasion, and EMT of LC cells. In addition, circ_0002980 specifically binds to miR-1303, and the accelerated effect of miR-1303 overexpression on LC progression was partially reversed by circ_0002980. Moreover, miR-1303 can also target CADM2, and CADM2-mediated prevention can also be attenuated by miR-1303 overexpression. Conclusions: In LC cells, circ_0002980 upregulation prevents cell proliferation, metastasis, and EMT by affecting the miR-1303/CADM2 axis. Therefore, this axis may be a novel therapeutic target in LC.

show abstract

Section: Discussionmentioning

confidence: 99%

hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Wang,

Li,

et al. 2023

Aging

View full text Add to dashboard Cite

show abstract

“…Despite this, the precise contributions of circRNAs to AGA remain largely unexplored. Through an extensive examination of circRNA expression patterns that exploited whole-transcriptome sequencing, we identified circAGK as a promising target for focused therapeutic strategies in AGA [30] (see Fig. 2 ).…”

Section: Application Of Omics Technologies To the Study Of Agamentioning

confidence: 99%

Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives

Li,

Dong,

Wan

et al. 2024

Computational and Structural Biotechnology Journal

View full text Add to dashboard Cite

Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis

Wei,

Zhao,

et al. 2024

Aesth Plast Surg

Self Cite

View full text Add to dashboard Cite

Botulinum toxin type A (BTXA) has been shown to be effective in androgenetic alopecia (AGA), but its effect on dermal papillary cell (DPC) apoptosis is not yet clear. Non-coding RNA plays pivotal roles in the development of AGA. In this study, we investigated the molecular mechanism of BTXA in dihydrotestosterone(DHT)-induced apoptosis of DPCs. The expressions of circ_0135062, miR-506-3p and Bax were detected by qRT-PCR. RNA pulldown and dual luciferase assays were used to analyze binding evidence. Cell viability was validated using the cell counting kit-8 assay, and cell apoptosis was determined by ow cytometry, TUNEL assay, and Western blot. Our results revealed that BTXA inhibited apoptosis of DPCs treated with DHT and that overexpression of circ_0135062 antagonized the protection of BTXA in DHT-treated DPCs. The miR-506-3p interacted with Bax, and miR-506-3p inhibited apoptosis of DPCs against DHT-mediated damage by silencing Bax. Additionally, circ_0135062 served as a miR-506-3p sponge and inhibited miR-506-3p targeting Bax expression. In conclusion, BTXA exerted an antiapoptotic effect on DHT-induced DPC injury via the circ_0135062/miR-506-3p/Bax axis.

show abstract

CircAGK regulates high dihydrotestosterone‐induced apoptosis in DPCs through the miR‐3180‐5p/BAX axis

Cited by 5 publications

References 34 publications

hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis

Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives

Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis

Contact Info

Product

Resources

About