Abstract:Numerous studies have indicated enrichment of circular RNA (circRNA) in the brain takes on a momentous role in cerebral ischemia‐reperfusion (CIR) injury. A recent study discovered a novel circCRIM1, was highly expressed in the middle cerebral artery occlusion‐reperfusion (MCAO/R) model. Nevertheless, its specific biological function remained unknown. The study was to explore circCRIM1 in CIR‐induced neuronal apoptosis. As measured, circCRIM1 and TXNIP were up‐regulated, while miR‐141‐3p was down‐regulated in … Show more
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