<scp>CircWHSC1</scp> serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via <scp>miR</scp>‐590‐5p/<scp>SOX5</scp> axis

Wu, Bin; Wang, Xisheng; Yu, Ronghai; Xue, Xingkui

doi:10.1002/tox.23879

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…Lung cancer is the most prevalent cancer type that involves different mechanisms 45,46 . A previous report has shown that PRMT6 is largely expressed in lung cancer tissues, and its abrogation significantly suppressed the growth of lung cancer cells 47 .…”

Section: Discussionmentioning

confidence: 99%

Yifei Sanjie formula alleviates lung cancer progression via regulating PRMT6‐YBX1‐CDC25A axis

Tang,

Yin,

Chen

et al. 2024

Environmental Toxicology

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Lung cancer (LC) is the most prevalent cancer type, with a high mortality rate worldwide. The current treatment options for LC have not been particularly successful in improving patient outcomes. Yifei Sanjie (YFSJ), a well‐applicated traditional Chinese medicine formula, is widely used to treat pulmonary diseases, especially LC, yet little is known about its molecular mechanisms. This study was conducted to explore the molecular mechanism by which YFSJ ameliorated LC progression. The A549, NCI‐H1975, and Calu‐3 cells were treated with the YFSJ formula and observed for colony number, apoptosis, migration, and invasion properties recorded via corresponding assays. The PRMT6‐YBX1‐CDC25A axis was tested and verified through luciferase reporter, RNA immunoprecipitation, and chromatin immunoprecipitation assays and rescue experiments. Our results demonstrated that YFSJ ameliorated LC cell malignant behaviors by increasing apoptosis and suppressing proliferation, migration, and invasion processes. We also noticed that the xenograft mouse model treated with YFSJ significantly reduced tumor growth compared with the control untreated group in vivo. Mechanistically, it was found that YFSJ suppressed the expression of PRMT6, YBX1, and CDC25A, while the knockdown of these proteins significantly inhibited colony growth, migration, and invasion, and boosted apoptosis in LC cells. In summary, our results suggest that YFSJ alleviates LC progression via the PRMT6‐YBX1‐CDC25A axis, confirming its efficacy in clinical use. The findings of our study provide a new regulatory network for LC growth and metastasis, which could shed new insights into pulmonary medical research.

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Section: Discussionmentioning

confidence: 99%

Yifei Sanjie formula alleviates lung cancer progression via regulating PRMT6‐YBX1‐CDC25A axis

Tang,

Yin,

Chen

et al. 2024

Environmental Toxicology

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Section: Sox5 In Multiple Human Cancersmentioning

confidence: 99%

“…Non-small cell lung cancer (NSCLC) is the most common histological type of lung cancer (81). Many studies have suggested that SOX5, as an oncogene, is involved in the occurrence and development of NSCLC (61). Li et al found that SOX5 was highly expressed in tissues and cell lines of NSCLC, and highly expressed SOX5 could promote the development of NSCLC (62), and suggested that the mechanism might be to drive the malignant potential of NSCLC through interaction with YAP1 (82).…”

Section: Lung Cancermentioning

confidence: 99%

Biological functions and therapeutic potential of SRY related high mobility group box 5 in human cancer

Xue,

Xiang,

Cai

et al. 2024

Front. Oncol.

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Cancer is a heavy human burden worldwide, with high morbidity and mortality. Identification of novel cancer diagnostic and prognostic biomarkers is important for developing cancer treatment strategies and reducing mortality. Transcription factors, including SRY associated high mobility group box (SOX) proteins, are thought to be involved in the regulation of specific biological processes. There is growing evidence that SOX transcription factors play an important role in cancer progression, including tumorigenesis, changes in the tumor microenvironment, and metastasis. SOX5 is a member of SOX Group D of Sox family. SOX5 is expressed in various tissues of human body and participates in various physiological and pathological processes and various cellular processes. However, the abnormal expression of SOX5 is associated with cancer of various systems, and the abnormal expression of SOX5 acts as a tumor promoter to promote cancer cell viability, proliferation, invasion, migration and EMT through multiple mechanisms. In addition, the expression pattern of SOX5 is closely related to cancer type, stage and adverse clinical outcome. Therefore, SOX5 is considered as a potential biomarker for cancer diagnosis and prognosis. In this review, the expression of SOX5 in various human cancers, the mechanism of action and potential clinical significance of SOX5 in tumor, and the therapeutic significance of Sox5 targeting in cancer were reviewed. In order to provide a new theoretical basis for cancer clinical molecular diagnosis, molecular targeted therapy and scientific research.

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CircWHSC1 (CircNSD2): A Novel Circular RNA in Multiple Cancers

Zhang,

Yuan,

Wang

et al. 2024

Clin Med Insights Oncol

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Circular RNAs (circRNAs) are a type of non-coding RNA (ncRNA) that possesses a unique single-stranded circular structure. They are primarily formed through alternative splicing of pre-mRNA (messenger RNA). The primary biological function of circRNAs is to regulate gene expression at both the transcriptional and post-transcriptional levels. Recent studies have increasingly demonstrated a close association between the dysregulation of circRNAs and the progression of diverse cancers, where they can function as either tumor suppressors or oncogenes. circWHSC1 (circNSD2) is a circular ncRNA that originates from the first 2 exons of the Wolf-Hirschhorn syndrome candidate gene (WHSC1). As Chen 2019 discovery that circWHSC1 (circNSD2) functions as a sponge for miRNAs and promotes cancer, this circRNA has garnered significant interest among researchers. circWHSC1 (circNSD2) has been found to be up-regulated in various malignant tumors, including nasopharyngeal carcinoma, lung cancer, breast cancer, liver cancer, colorectal cancer, ovarian cancer, cervical cancer, and endometrial cancer. It exerts its effects on cancer by either inhibiting or promoting the expression of related genes through direct or indirect pathways, ultimately affecting cancer proliferation, invasion, and prognosis. This article provides a comprehensive review and discussion of the biological roles of circWHSC1 (circNSD2) and its target genes in various cancers, as well as the latest research progress on related molecular biological regulatory mechanisms. Furthermore, the potential significance of circWHSC1 (circNSD2) in future clinical applications and transformations is thoroughly analyzed and discussed.

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CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

Cited by 3 publications

References 47 publications

Yifei Sanjie formula alleviates lung cancer progression via regulating PRMT6‐YBX1‐CDC25A axis

Yifei Sanjie formula alleviates lung cancer progression via regulating PRMT6‐YBX1‐CDC25A axis

Biological functions and therapeutic potential of SRY related high mobility group box 5 in human cancer

CircWHSC1 (CircNSD2): A Novel Circular RNA in Multiple Cancers

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