COin Gastrointestinal Physiology and Protection

Self-assembled carbon monoxide nanogenerators managing sepsis through scavenging multiple inflammatory mediators

“…Heme Oxygenase-1 (HO-1) and its catalytic product, CO, significantly contribute to endogenous protective mechanisms aganist cellular stress, participating in the regulation of oxidative stress, inflammation, autophagy, pyroptosis and other pathophysiological processes [ [17] , [18] , [19] ]. Consequently, the exogenous delivery of CO can trigger a cascade of cellular protection mechanisms during stress and inflammation, activating essential endogenous defense functions [ [20] , [21] , [22] ]. Additionally, it is worth noting that CO is a non-radical group and poses no toxic side effects at low doses, making it an ideal gas molecule for sepsis treatment [ 23 ].…”