CORS (CROM20): A new high‐prevalence antigen in the Cromer blood group system

Abstract

The Cromer blood group system consists of 19 antigens (16 of high prevalence and 3 of low prevalence). This study describes the identification and characterization of a new Cromer high-prevalence antigen, named CORS. The CORSnegative proband carries a c.713G>A substitution in the CD55 gene, resulting in the substitution of glycine 238 into a glutamic acid (p.Gly238Glu).

When recombinant proteins can replace rare red cells in immunohematology workups

“…Since 1996, multiple studies have exploited soluble or cell membrane‐bound recombinant proteins to screen human sera for blood‐group‐specific antibodies (Table 1). 27,29,32,44–95 There are 190 red cell antigens classified as high‐prevalence by the ISBT (see web resources) 96 . To identify antibody specificities against all high‐prevalence antigens, up to 190 distinct red cells lacking high‐prevalence antigens or lacking the whole carrier protein would be needed.…”