<scp>COVID</scp>‐19 infection risk in patients on immunosuppressive/immunomodulator therapy: A single center study

Ghiasi, Maryam; Nasimi, Maryam; Ghandi, Narges; Lajevardi, Vahideh; Abedini, Robabeh; Azizpour, Arghavan; Ansari, Mahshid Sadat; Kheiltash, Azita; Balighi, Kamran

doi:10.1111/dth.15126

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…[10] Other studies found that patients who use immunosuppressive drugs have also increased risk of mortality and longer hospitalization period. [11,12] There is one issue to mention, none of these studies include AIH disease; they mainly included rheumatoid diseases, dermatologic cases, and cancer patients. We might say that there is no consensus whether immunosuppression causes severe COVID-19 disease vice versa.…”

Section: Autoimmune Hepatitis (Aih)mentioning

confidence: 99%

The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants

Sahin

2024

Hepatology Forum

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Coronavirus disease-2019 (COVID-19) is a novel multisystemic viral disease caused pandemic. The disease impact involves liver and associated systems. Undoubtedly, host genetic background influences the predisposition and prediction of infection. Variants among human populations might increase susceptibility or protect against severe outcomes. In this manner, rs738409 variant of patatin-like phospholipase domain-containing protein 3 gene appears to be protective in some populations in spite of its aggravating effect on non-alcoholic fatty liver diseases (NAFLDs) and steatohepatitis. DRB1*15:01 allele of human leukocyte antigen is associated with protective effect in European and Japanese populations. DRB1*03:01 contrarily increases the susceptibility of severe COVID-19 infection in European populations. rs1260326 in glucokinase regulatory protein gene, rs112875651 in tribbles homolog 1 gene, rs429358 in apolipoprotein 1, and rs58542926 in transmembrane 6 superfamily 2 alleles are found related with NAFLD and obesity; thus, hypercoagulability and severe COVID-19 outcomes. In chronic or acute liver diseases, comorbid syndromes are the key factors to explain increased severity. There might not be a direct association between the variant and severe COVID-19 infection. As it is concluded, there are genes and variants known and unknown yet to be studied to reveal the association with disease severity.

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Section: Autoimmune Hepatitis (Aih)mentioning

confidence: 99%

The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants

Sahin

2024

Hepatology Forum

View full text Add to dashboard Cite

show abstract

COVID‐19 infection risk in patients on immunosuppressive/immunomodulator therapy: A single center study

Cited by 1 publication

References 11 publications

The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants

The pleiotropic approach to coronavirus disease-19 pathogenesis: The impact of liver diseases associated host genetic variants

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