2022
DOI: 10.1002/mds.28998
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CRISPR/Cas9‐Based Functional Genomics in Human Induced Pluripotent Stem Cell–Derived Models: Can “the Stars Align” for Neurodegenerative Diseases?

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“…Since atrophy does not equal dysfunction in the sense of a clinical impairment, it is time to ask if neurodegenerative disease is a term that sets us on the wrong paths, especially as it is not just the neurons that are important for functioning brains. Moreover, there are marked differences in genetic background and environmental effects in, for example, the quartet of AD, PD, ALS, and HD (Table 1) [44,[54][55][56][57]. The differences in their geographical distributions are also clear [58].…”
Section: Neurodegeneration-the Ugly Duckling or A Red Herring?mentioning
confidence: 99%
“…Since atrophy does not equal dysfunction in the sense of a clinical impairment, it is time to ask if neurodegenerative disease is a term that sets us on the wrong paths, especially as it is not just the neurons that are important for functioning brains. Moreover, there are marked differences in genetic background and environmental effects in, for example, the quartet of AD, PD, ALS, and HD (Table 1) [44,[54][55][56][57]. The differences in their geographical distributions are also clear [58].…”
Section: Neurodegeneration-the Ugly Duckling or A Red Herring?mentioning
confidence: 99%