<scp>CXCR</scp>4‐mediated osteosarcoma growth and pulmonary metastasis is suppressed by Micro<scp>RNA</scp>‐613

Zhu, Yong; Tang, Lanhua; Zhao, Shushan; Sun, Buhua; Cheng, Liang; Tang, Yifu; Luo, Zhenguo; Lin, Zhenghua; Zhu, Jianxi; Zhu, Wan; Zhao, Ruibo; Lu, Bin; Long, Haitao

doi:10.1111/cas.13653

Cited by 46 publications

(33 citation statements)

References 36 publications

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“… 28 – 30 Zhu et al reported that MiR-613 directly suppressed CXCR4 expression and then decreased the proliferation, migration, and induced apoptosis of osteosarcoma cells. 31 Another report found that lncRNA CYTOR promoted the invasion and migration of nasopharyngeal carcinoma cells by targeting the miR-613/ANXA2 axis. 32 Of note, the target gene of miR-613 in lung cancer was recently reported.…”

Section: Discussionmentioning

confidence: 99%

<p>LncRNA RMRP Promotes Cell Proliferation and Invasion Through miR-613/NFAT5 Axis in Non-Small Cell Lung Cancer</p>

Yang¹,

Ke²,

Zhou³

2020

OTT

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Background The abnormal expression of RMRP and miR-613 was respectively associated with the pathogenesis of lung cancer, but the role of the RMRP/miR-613 axis in NSCLC has not been studied. Methods In this report, we measured the levels of RMRP in clinical NSCLC samples and cell lines. The target gene of RNA was predicted by online tools and verified by Luciferase reporter assay. Moreover, the function and regulatory mechanism of RMRP in the progression of cancer were further investigated. Results Our data showed that the expression of RMRP in NSCLC tissues and cell lines was both up-regulated. Functionally, RMRP promoted the proliferation and metastasis of A549 and H1299 cells. Luciferase reporter assay confirmed that RMRP was the sponger of miR-613, and NFAT5 is the direct target of miR-613. Functional acquisition and loss-of-function strategies further confirmed that RMRP induces the up-regulation of NFAT5 expression through competitive binding with miR-613, leading to promote the progression and metastasis potential of lung cancer cells. Conclusion Collectively, our findings emphasized the importance of RMRP in the development of NSCLC, which may provide a new therapeutic target and potential diagnostic biomarker for NSCLC therapy.

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Section: Discussionmentioning

confidence: 99%

<p>LncRNA RMRP Promotes Cell Proliferation and Invasion Through miR-613/NFAT5 Axis in Non-Small Cell Lung Cancer</p>

Yang¹,

Ke²,

Zhou³

2020

OTT

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Section: Introductionmentioning

confidence: 99%

“…Osteosarcoma is a malignant primary bone tumor, which occurs mainly in adolescents and young adults . In patients with metastatic osteosarcoma or with distant disease relapse after localized disease treatment, the long‐term overall survival (OS) rate is <20% . Currently, treatment modalities for osteosarcoma include surgery, chemotherapy, radiotherapy, and immunotherapy; among these, radical resection and implant selection are very crucial .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

Dai

Tang

et al. 2019

J Biomed Mater Res

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Osteosarcoma is a malignant primary bone tumor, which often associates with pulmonary metastasis. The radical surgery of osteosarcoma often requires internal orthopedic implants. Therefore, implants with antitumor properties should be developed. Magnesium (Mg) and its alloys possess great potential as orthopedic materials, given their biodegradable properties, superior osteogenesis performance, and antitumor features. However, problems arise with their uncontrolled degradation rates and their unknown antitumor mechanisms. In our study, when compared with pure Mg, the rare element silver alloyed with yttrium (Ag–Y) could extremely enhance the corrosion resistance of these elements, giving the Ex–Mg–1Ag–1Y alloy better anticorrosion rates. Here, we implanted the Ex–Mg–1Ag–1Y alloy and pure Mg and Ti alloy in vivo around tumors in nude mice (BALB/c). Notably, the local tumor weight in Mg alloy and pure Mg groups were much smaller than that in Ti alloy group in 36 days after surgery (6.59 ± 0.70, 6.76 ± 0.62, and 8.54 ± 0.56 g), while the general scores of lung metastasis in Mg alloy and pure Mg groups were also lower than Ti alloy group (64.50 ± 7.64, 62.73 ± 7.84, and 87.60 ± 9.43). Therefore, the Mg and Ex–Mg–1Ag–1Y alloy, both demonstrated resisting effects against local tumor growth and pulmonary metastasis, which could be performed by changing the extracellular acidosis microenvironment, elevating the Mg concentration, suppressing C–X–C chemokine receptor type 4 (CXCR4) levels, and increasing prostacyclin (PGI2) synthesis. Our work revealed that the Ex–Mg–1Ag–1Y alloy may be a promising orthopedic implant for treating osteosarcoma due to its better corrosion resistance and antitumor attributes. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2537–2548, 2019.

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“…9,10 For instance, miR-506-3p functions as a tumour suppressor by suppressing the proliferation and metastasis of OS cells via targeting RAB3D. 12 While, our previous study reports that miR-92a is overexpressed in OS tissues and facilitates tumour growth of OS via suppressing phosphatase and tensin homologue (PTEN) and AKT signalling pathway. 12 While, our previous study reports that miR-92a is overexpressed in OS tissues and facilitates tumour growth of OS via suppressing phosphatase and tensin homologue (PTEN) and AKT signalling pathway.…”

mentioning

confidence: 99%

“…11 MiR-613 inhibits OS cell proliferation and migration, and induces apoptosis by targeting chemokine receptor 4 (CXCR4). 12 While, our previous study reports that miR-92a is overexpressed in OS tissues and facilitates tumour growth of OS via suppressing phosphatase and tensin homologue (PTEN) and AKT signalling pathway. 13 Recently, A new tumour-suppressive miR-876-5p has been found to play important roles in a variety of tumours including lung cancer, 14 oesophageal squamous cell carcinoma (ESCC), 15 hepatocellular carcinoma (HCC) 16,17 and head and neck squamous cell carcinoma (HNSCC).…”

mentioning

confidence: 99%

MicroRNA‐876‐5p inhibits cell proliferation, migration and invasion by targeting c‐Met in osteosarcoma

Xie

Xiao

Wang

et al. 2019

J Cellular Molecular Medi

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Recently, aberrant expression of miR‐876‐5p has been reported to participate in the progression of several human cancers. However, the expression and function of miR‐876‐5p in osteosarcoma (OS) are still unknown. Here, we found that the expression of miR‐876‐5p was significantly down‐regulated in OS tissues compared to para‐cancerous tissues. Clinical association analysis indicated that underexpression of miR‐876‐5p was positively correlated with advanced clinical stage and poor differentiation. More importantly, OS patients with low miR‐876‐5p level had a significant shorter overall survival compared to miR‐876‐5p high‐expressing patients. In addition, gain‐ and loss‐of‐function experiments demonstrated that miR‐876‐5p restoration suppressed whereas miR‐876‐5p knockdown promoted cell proliferation, migration and invasion in both U2OS and MG63 cells. In vivo studies revealed that miR‐876‐5p overexpression inhibited tumour growth of OS in mice. Mechanistically, miR‐876‐5p reduced c‐Met abundance in OS cells and inversely correlated c‐Met expression in OS tissues. Herein, c‐Met was recognized as a direct target of miR‐876‐5p using luciferase reporter assay. Notably, c‐Met restoration rescued miR‐876‐5p attenuated the proliferation, migration and invasion of OS cells. In conclusion, these findings indicate that miR‐876‐5p may be used as a potential therapeutic target and promising biomarker for the diagnosis and prognosis of OS.

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CXCR4‐mediated osteosarcoma growth and pulmonary metastasis is suppressed by MicroRNA‐613

Cited by 46 publications

References 36 publications

<p>LncRNA RMRP Promotes Cell Proliferation and Invasion Through miR-613/NFAT5 Axis in Non-Small Cell Lung Cancer</p>

<p>LncRNA RMRP Promotes Cell Proliferation and Invasion Through miR-613/NFAT5 Axis in Non-Small Cell Lung Cancer</p>

Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

MicroRNA‐876‐5p inhibits cell proliferation, migration and invasion by targeting c‐Met in osteosarcoma

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