CYP1A1 rs1048943 and rs4646903 polymorphisms associated with laryngeal cancer susceptibility among Asian populations: a meta‐analysis

Abstract

Many studies have investigated the association between CYP1A1 rs1048943 and rs4646903 polymorphisms and laryngeal cancer risk, but their results have been inconsistent. The PubMed and CNKI were searched for case–control studies published up to 01 July 2015. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In this meta‐analysis, we assessed 10 published studies involving comprising 748 laryngeal cancer cases and 1558 controls of the association between CYP1A1 rs1048943 and rs4646903 polymorphisms and laryngeal cancer risk. For CYP1A1 rs1048943 of the homozygote G/G and G allele carriers (A/G + G/G) versus A/A, the pooled ORs were 1.77 (95% CI = 1.28–2.81, P = 0.007 for heterogeneity) and 1.86 (95% CI = 1.45–2.40, P = 0.000 for heterogeneity). For CYP1A1 rs4646903 of the homozygote G/G and G allele carriers (A/G + G/G) versus A/A, the pooled ORs were 1.53 (95% CI = 1.31–2.21, P = 0.012 for heterogeneity) and 1.33(95% CI = 1.04–1.71, P = 0.029 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were found among Asians for both the G allele carriers and homozygote G/G. However, no significant associations were found in Caucasian population all genetic models. These results from the meta‐analysis suggest that CYP1A1 rs1048943 and rs4646903 polymorphisms contribute to risk of laryngeal cancer among Asian populations.

Genetic Variations, Exposure to Persistent Organic Pollutants and Breast Cancer Risk – A Greenlandic Case–Control Study

“…Meta‐analyses evaluating the effect of CYP19A1 *19C>T , CYP1A1 Ile462Val , CYP1B1 Leu432Val and COMT Val158Met did, in line with our study, not find any significant associations with breast cancer risk. For CYP19A1 *19C>T and COMT Val158Met, no associations were found overall or when stratifying by ethnicity .…”

Association of Smoking and XPG, CYP1A1, OGG1, ERCC5, ERCC1, MMP2, and MMP9 Gene Polymorphisms with the early detection and occurrence of Laryngeal Squamous Carcinoma

“…In addition, Lourenço et al studied 142 patients with head and neck squamous cell carcinoma and 142 control subjects and found that CYP1A1, GSTM1 and GSTT1 were closely related to head and neck cancer especially in patients with a severe smoking level 15 . A meta-analysis in 2016 found that carriers of the G allele for CYP1A1 rs1048943 and rs4646903 had a significantly increased risk of laryngeal cancer in Asian populations; 10 trials were included in the study, involving 748 patients with laryngeal cancer and 1558 control subjects 16 . These results are consistent with the present finding suggesting that allele G carriers at rs1048943 have an increased risk of laryngeal carcinoma.…”

Qual o papel dos genes de metabolização de xenobióticos de fase I e genes relacionados com a ação da nicotina no risco de desenvolvimento do câncer de cabeça e pescoço?

“…xenobióticos (Ingelman-Sundbarg, 2004;Nebert e Dalton, 2006 (Tanimotoa et al 1999;Sato et al, 2000;Ho et al, 2007;Singh et al, 2014;Yu et al, 2014;Zeng et al, 2016). Porém tais associações são controversas em alguns estudos.…”

“…A variante CYP1A1*2C (rs1048943), que corresponde à troca da base A pela G, com alteração do aminoácido isoleucina para valina (Colombo e Rahal, 2009;Yousef et al, 2012), produz também uma enzima de atividade aumentada, que tem sido associada ao aumento do risco de desenvolvimento de neoplasias da cavidade oral e da laringe em populações Asiáticas (Sato et al, 2000;Zeng et al, 2016).…”

“…No presente estudo, o consumo de cigarros foi o principal fator de risco associado ao desenvolvimento de tumores malignos da cabeça e pescoço. Os polimorfismos do gene CYP1A1 estudados na presente investigação, rs4646903 e rs1048943, já foram associados com o aumento do risco de desenvolvimento de neoplasias de cabeça e pescoço, de cavidade oral e orofaringe em populações de origem Asiática, como a Japonesa, Indiana e a Chinesa (Sato et al, 2000;Ho et al, 2007;Tanimotoa et al, 1999;Yu et al, 2014;Zeng et al, 2016). De acordo com dados da literatura, nessas populações as variantes estudadas são encontradas com maior frequência, chegando a atingir 30%, enquanto que nos Caucasianos a frequência da variante rs4646903…”