<scp>DCE‐MRI</scp> findings of invasive aspergillosis in patient with acute myeloid leukemia

Araz, Ömer; Karaman, Adem; Uçar, Elif Yılmazel; Bilen, Yusuf; Subaşi, İrmak Durur

doi:10.1111/crj.12061

Cited by 5 publications

(3 citation statements)

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“…Although morphological assessments of cystic‐cavitary lung lesions have been reported in previous studies with CT and MRI, only a few case reports have investigated the dynamic features of lesions . DCE‐MRI studies of the chest have primarily focused on solid lesions and, no previous study has investigated the role of DCE‐MRI in cystic‐cavitary lung lesions. Our results in cystic‐cavitary lesions were concordant with the previous reports performed in solid lung lesions.…”

Section: Discussionmentioning

confidence: 99%

Added value of DCE‐MRI in the management of cystic‐cavitary lung lesions

et al. 2015

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Background and objective:We evaluated the added value of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to CT in the evaluation of cystic-cavitary lung lesions.We aimed to compare morphological parameters, including wall thickness and inner wall irregularity, and to determine whether DCE-MRI with morphological and dynamic parameters was useful in indeterminate lesions.We also aimed to investigate the added value of DCE-MRI in terms of whether to biopsy, and if so the site of biopsy. Methods: This prospective study included 39 consecutive patients with cystic and/or cavitary lung lesions detected by CT who then underwent additional DCE-MRI. After initial evaluation, the lesions were classified as benign, indeterminate or malignant and the findings of CT and DCE-MRI compared with each other by considering the final diagnosis that was determined by histopathological findings and clinical evaluation and follow up. Results:The mean values for wall thickness obtained by DCE-MRI were lower and the range of wall thickness for indeterminate lesions was narrower than those obtained by CT (5.50-11.50 mm and 5.75-13.50 mm for DCE-MRI and CT), and inner wall irregularity on DCE-MRI was more sensitive in malignant lesions. Also, DCE-MRI obviated biopsy in three benign patients and changed the biopsy site in two patients. Conclusion: Our study suggests that DCE-MRI is helpful in indeterminate cystic-cavitary lung lesions, with morphological and dynamic features. It narrowed the range of wall thickness used for indeterminate lesions, was more sensitive than CT in determining malignant inner wall irregularity, and was also useful in determining the need for and appropriate site of biopsy.

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Section: Discussionmentioning

confidence: 99%

Added value of DCE‐MRI in the management of cystic‐cavitary lung lesions

et al. 2015

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“…In diffusion-weighted images (DWI), lesion walls showed restricted diffusion. In postcontrast phase dynamic contrast images, lesion walls showed enhanced contrast (wash in 80%-90%), and there was no washout in late-phase images [57] .…”

Section: Airway Invasive Aspergillosis Is An Uncommon Invasive Diseasmentioning

confidence: 93%

An update of clinical characteristics and imaging findings of pulmonary aspergillosis

Sah

Liu

Ganganah

et al. 2015

IJDI

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Pulmonary aspergillosis (PA) is a clinical spectrum of rapidly progressive potentially fatal opportunistic mycosis usually caused by Aspergillus organisms. In the recent years, the number of patients with invasive pulmonary aspergillosis (IPA) has increased and it remains a major cause of morbidity and mortality in immunocompromised patients. Chest CT plays an important role in the early diagnosis of IPA and should be included in the investigative protocol. Typical imaging findings of IPA include nodule, consolidation, the halo sign, the hypodense sign and the air crescent sign. CT Angiography (CTA) has a higher sensitivity for detecting angioinvasive aspergillosis. However, the diagnosis of pulmonary aspergillosis remains challenging radiologically in immunocompetent chronic obstructive pulmonary disease (COPD) and critically ill patients in intensive care unit (ICU) because of the non-specific CT findings and further studies are needed to establish the confirm diagnosis.

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“…By using an advanced MR pulse sequence with ultra-short echo times, pathological changes within the infected lung were visually and quantitatively detectable and with a high degree of sensitivity. In humans, dynamic contrast-enhanced MRI (DCE-MRI) might also be useful for imaging IPA in immunosuppressed acute myeloid leukemia patients ( Araz et al, 2014 ).…”

Section: Aspergillosis Imaging With Computed Tomography and Magnetic mentioning

confidence: 99%

Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright

Thornton

2018

Front. Microbiol.

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Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of immuno-compromised humans caused by the ubiquitous environmental mold Aspergillus. Biomarker tests for the disease lack sensitivity and specificity, and culture of the fungus from invasive lung biopsy is slow, insensitive, and undesirable in critically ill patients. A computed tomogram (CT) of the chest offers a simple non-intrusive diagnostic procedure for rapid decision making, and so is used in many hematology units to drive antifungal treatment. However, radiological indicators that raise the suspicion of IPA are either transient signs in the early stages of the disease or not specific for Aspergillus infection, with other angio-invasive molds or bacterial pathogens producing comparable radiological manifestations in a chest CT. Improvements to the specificity of radiographic imaging of IPA have been attempted by coupling CT and positron emission tomography (PET) with [18F]fluorodeoxyglucose ([18F]FDG), a marker of metabolic activity well suited to cancer imaging, but with limited use in invasive fungal disease diagnostics due to its inability to differentiate between infectious etiologies, cancer, and inflammation. Bioluminescence imaging using single genetically modified strains of Aspergillus fumigatus has enabled in vivo monitoring of IPA in animal models of disease. For in vivo detection of Aspergillus lung infections in humans, radiolabeled Aspergillus-specific monoclonal antibodies, and iron siderophores, hold enormous potential for clinical diagnosis. This review examines the different experimental technologies used to image IPA, and recent advances in state-of-the-art molecular imaging of IPA using antibody-guided PET/magnetic resonance imaging (immunoPET/MRI).

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DCE‐MRI findings of invasive aspergillosis in patient with acute myeloid leukemia

Cited by 5 publications

References 1 publication

Added value of DCE‐MRI in the management of cystic‐cavitary lung lesions

Added value of DCE‐MRI in the management of cystic‐cavitary lung lesions

An update of clinical characteristics and imaging findings of pulmonary aspergillosis

Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright

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