<scp>DNA</scp> base excision repair proteins <scp>APE</scp>‐1 and <scp>XRCC</scp>‐1 are overexpressed in oral tongue squamous cell carcinoma

Santana, Thalita; Sá, Melka Coelho; Santos, Edilmar de Moura; Galvão, Hébel Cavalcanti; Coletta, Ricardo D.; Freitas, Roseana de Almeida

doi:10.1111/jop.12529

Cited by 19 publications

(14 citation statements)

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“…Next, another study done on almost the same set of genes but on myeloproliferative neoplasm ( n = 133) treated with hydroxyurea has established a role of BER genes in progression and clinical evolution of neoplasm (Azevedo et al 2018). Further, the study by Santana et al (2016) has shown overexpression of AP-1 and XRCC-1 in oral tongue squamous cell carcinoma ( n = 82). A high expression of XRCC-1 was significantly associated with early tumor stage.…”

Section: Dna Repair In Cancer Initiation and Progressionmentioning

confidence: 89%

DNA repair in cancer initiation, progression, and therapy—a double-edged sword

Kiwerska

Szyfter

2019

J Appl Genetics

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Genomic and mitochondrial DNA molecules are exposed continuously for a damaging activity of chemical, physical, and internal genotoxicants. When DNA repair machinery is not working efficiently, the generation of DNA lesions and mutations leads to carcinogenic transformation. The high number of mutation going up to 10 5 per cell was recognized as a driving force of oncogenesis. Moreover, a high activity of DNA repair genes was hypothesized as a predisposition to metastasis. DNA repair potential has to be taken into account attempting to chemo-and/or radiotherapy. A low activity of DNA repair genes makes tumor cells more sensitive to therapy, but on the other hand, non-tumor cells getting lesions could form second primary cancer. Contrary, high activity of DNA repair genes counteracts attempted therapy. It means an individualized therapy based on recognition of DNA repair potential is recommended.

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Section: Dna Repair In Cancer Initiation and Progressionmentioning

confidence: 89%

DNA repair in cancer initiation, progression, and therapy—a double-edged sword

Kiwerska

Szyfter

2019

J Appl Genetics

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“…Smoking is the main etiological factor associated with its development. 3 Although the epidemiological profile has changed over time, with considerable regional variations, there is still higher prevalence of OTSCC among males, as they have greater exposure to risk factors. 1,3 OTSCC exhibits an aggressive biological behavior and has usually a poorer prognosis when compared to tumors at other sites.…”

Section: Introductionmentioning

confidence: 99%

“…3 Although the epidemiological profile has changed over time, with considerable regional variations, there is still higher prevalence of OTSCC among males, as they have greater exposure to risk factors. 1,3 OTSCC exhibits an aggressive biological behavior and has usually a poorer prognosis when compared to tumors at other sites. 4,5,6,7 Lower lip squamous cell carcinoma (LLSCC) is more common among male patients above the age of 50 years and solar radiation is the main etiological factor.…”

Section: Introductionmentioning

confidence: 99%

“…18,19 Studies indicate that the expression of these proteins is deregulated in various neoplastic processes, including SCC; however, the role of these proteins in the biological behavior of OTSCC and LLSCC remains controversial. 3,20 In this context, studies analyzing the role of the DNA repair proteins XRCC1 and XPF in OTSCC are scarce and, so far, no study has evaluated their immunoexpression in LLSCC. 3,21,22 The objective of the present study was to investigate possible associations of the two DNA repair proteins XPF and XRCC1 with clinical and histopathological parameters in OTSCC and LLSCC, analyzing the role of these proteins in the two neoplastic processes that differ in terms of etiological factors, biological behavior, and prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical expression of DNA repair proteins in oral tongue and lower lip squamous cell carcinoma

et al. 2020

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The DNA repair system involves genes and proteins that are essential for the maintenance of genome integrity and the consequent control of various cellular processes. Alterations in these genes and proteins play a role in tumor development and progression and might be associated with prognosis. The aims of this study were to analyze the immunoexpression of two DNA repair proteins, XPF and XRCC1, in lower lip squamous cell carcinoma (LLSCC) and oral tongue squamous cell carcinoma (OTSCC), and to investigate possible associations with clinical and histopathological parameters. The immunohistochemical expression of XPF and XRCC1 was analyzed semi-quantitatively in 40 cases each of LLSCC and OTSCC. The chi-squared test or Fisher's exact test, when appropriate, was used to investigate the association between expression of the proteins and clinicopathological characteristics. The cytoplasmic immunoexpression of XPF was high in OTSCC (95% of the cases analyzed) but low in LLSCC (52.5%). Among the clinicopathological parameters evaluated, a statistically significant association was observed between high nuclear expression of XRCC1 and the absence of regional lymph node metastasis in patients diagnosed with OTSCC (p=0.006). The high protein expression of XPF and XRCC1 in OTSCC and LLSCC suggests an important role in the development and progression of these tumors. Our study found an association between high nuclear expression of XRCC1 and the absence of loco-regional metastasis in cases diagnosed as OTSCC, suggesting a role of this protein in tumor progression.

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“…1 – 4 XRCC genes are involved in base excision repair (BER) and single-strand break in damaged DNA in human genome. 1 – 5 Molecular epidemiological studies have shown that XRCC genes are significantly associated with lung cancer, 6 – 9 oral cancer, 10 bladder cancer, 11 – 13 ovarian cancer, 14 , 15 esophageal cancer, 16 and gastric cancer. 17 – 23 Moreover, studies have revealed that XRCC gene polymorphism is highly variable in different ethnic populations.…”

Section: Introductionmentioning

confidence: 99%

DNA Repair Mechanism Gene, XRCC1A (Arg194Trp) but not XRCC3 (Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

Devi

Ahmed

Narain

et al. 2017

Technol Cancer Res Treat

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X-ray repair cross complementary group gene is one of the most studied candidate gene involved in different types of cancers. Studies have shown that X-ray repair cross complementary genes are significantly associated with increased risk of breast cancer in females. Moreover, studies have revealed that X-ray repair cross complementary gene polymorphism significantly varies between and within different ethnic groups globally. The present case–control study was aimed to investigate the association of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer in females from northeastern region of India. The present case–control study includes histopathologically confirmed and newly diagnosed 464 cases with breast cancer and 534 apparently healthy neighborhood community controls. Information on sociodemographic factors and putative risk factors were collected from each study participant by conducting face-to-face interviews. Genotyping of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) was carried out by polymerase chain reaction-restriction fragment length polymorphism. For statistical analysis, both univariate and multivariate logistic regression analyses were performed. We also performed stratified analysis to find out the association of X-ray repair cross complementary genes with the risk of breast cancer stratified based on menstrual status. This study revealed that tryptophan allele (R/W-W/W genotype) in X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer (adjusted odds ratio = 1.44, 95% confidence interval = 1.06-1.97, P < .05 for R/W-W/W genotype). Moreover, it was found that tryptophan allele (W/W genotype) at codon 194 of X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer in premenopausal females (crude odds ratio = 1.66, 95% confidence interval = 1.11-2.46, P < .05 for R/W-W/W genotype). The present study did not reveal any significant association of X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer. The present study has explored that X-ray repair cross complementary 1A (Arg194Trp) gene polymorphism is significantly associated with the increased risk of breast cancer in premenopausal females from northeastern region of India which may be beneficial for prognostic purposes.

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DNA base excision repair proteins APE‐1 and XRCC‐1 are overexpressed in oral tongue squamous cell carcinoma

Abstract: DNA base excision repair proteins APE-1 and XRCC-1 are upregulated in oral tongue squamous cell carcinoma, and XRCC-1 expression is associated with better clinical staging and nodal status.

Cited by 19 publications

References 30 publications

DNA repair in cancer initiation, progression, and therapy—a double-edged sword

DNA repair in cancer initiation, progression, and therapy—a double-edged sword

Immunohistochemical expression of DNA repair proteins in oral tongue and lower lip squamous cell carcinoma

DNA Repair Mechanism Gene, XRCC1A (Arg194Trp) but not XRCC3 (Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

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