<scp>DNA</scp>
            damage and
            <scp>NF‐κB</scp>
            inactivation implicate glycyrrhizic acid‐induced
            <scp>
              G
              <sub>1</sub>
            </scp>
            phase arrest in hepatocellular carcinoma cells

Wang, Wei‐Shu; Chen, Yu‐Shan; Kuo, Chen‐Yu; Tsai, Jung‐Fa; Hsu, Fei‐Ting; Chung, Jing Gung; Pan, Po‐Jung

doi:10.1111/jfbc.14128

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…Then, the PEI would reach the nuclear membrane without accumulation inside the nuclei where it creates local holes either by tiny disruption of the membrane or by PEI-supported holes . Through these holes, the PEI delivers its cargo and, in this study, it delivered the DOX to the nuclei. Consequently, the results revealed a cellular-enhanced active targeting of the HCC cells through the GA–GA receptor binding and subcellular (nuclear) targeting by the PEI-based shell to deliver the DOX to the nucleus.…”

Section: Resultsmentioning

confidence: 86%

Core–Shell Nanostructured Drug Delivery Platform Based on Biocompatible Metal–Organic Framework-Ligated Polyethyleneimine for Targeted Hepatocellular Carcinoma Therapy

et al. 2023

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Multifunctional nanosized metal–organic frameworks (NMOFs) have advanced rapidly over the past decade to develop drug delivery systems (DDSs). These material systems still lack precise and selective cellular targeting, as well as the fast release of the quantity of drugs that are simply adsorbed within and on the external surface of nanocarriers, which hinders their application in the drug delivery. Herein, we designed a biocompatible Zr-based NMOF with an engineered core and the hepatic tumor-targeting ligand, glycyrrhetinic acid grafted to polyethyleneimine (PEI) as the shell. The improved core–shell serves as a superior nanoplatform for efficient controlled and active delivery of the anticancer drug doxorubicin (DOX) against hepatic cancer cells (HepG2 cells). In addition to their high loading capacity of 23%, the developed nanostructure DOX@NMOF-PEI-GA showed an acidic pH-stimulated response and extended the drug release time to 9 days as well as enhanced the selectivity toward the tumor cells. Interestingly, the DOX-free nanostructures showed a minimal toxic effect on both normal human skin fibroblast (HSF) and hepatic cancer cell line (HepG2), but the DOX-loaded nanostructures exhibited a superior killing effect toward the hepatic tumor, thus opening the way for the active drug delivery and achieving efficient cancer therapy applications.

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Section: Resultsmentioning

confidence: 86%

Core–Shell Nanostructured Drug Delivery Platform Based on Biocompatible Metal–Organic Framework-Ligated Polyethyleneimine for Targeted Hepatocellular Carcinoma Therapy

et al. 2023

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“…Therefore, the expression level of intracellular γH2AX protein comes off as strong evidence of DNA damage in cells and is widely used in cancer research. Wang et al (2022) proposed that GA could inhibit DNA damage repair and induce apoptosis. The outcomes of this research suggested that the triggering mechanism of GA apoptosis may be achieved by inhibiting DNA damage repair.…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al. (2022) proposed that GA could inhibit DNA damage repair and induce apoptosis. The outcomes of this research suggested that the triggering mechanism of GA apoptosis may be achieved by inhibiting DNA damage repair.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizic acid inhibits DNA damage repair and enhances cisplatin‐induced apoptosis of melanoma cells

Bian,

Niu,

et al. 2024

Chem Biol Drug Des

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This research was designed to prospect the mechanism and impact of glycyrrhizic acid (GA) on DNA damage repair and cisplatin (CP)‐induced apoptosis of melanoma cells. First, human melanoma cell SK‐MEL‐28 was stimulated using GA for 24, 48, and 72 h. Then, the optimal treatment time and dosage were selected. After that, cell counting kit‐8 (CCK‐8) was employed for testing the cell viability, flow cytometry for the apoptosis, comet assay for the DNA damage of cells, and western blot for the cleaved‐Caspase3, Caspase3, Bcl‐2, and γH2AX protein expression levels. The experimental outcomes exhibited that as the GA concentration climbed up, the SK‐MEL‐28 cell viability dropped largely, while the apoptosis level raised significantly, especially at the concentration of 100 μm. In addition, compared with GA or CPtreatment only, CP combined with GA notably suppressed the viability of melanoma cells and promoted cell apoptosis at the cytological level. At the protein level, the combined treatment notably downregulated the Bcl‐2 and Caspase3 expression levels, while significantly upregulated the cleaved‐Caspase3 and γH2AX expression levels. Besides, CP + GA treatment promoted DNA damage at the DNA molecular level. Collectively, both GA and CP can inhibit DNA damage repair and enhance the apoptosis of SK‐MEL‐28 cells, and the synergistic treatment of both exhibits better efficacy.

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“…The cells were cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and 1% penicillinstreptomycin (PS). Following this, the cells underwent incubation in a controlled environment, maintained at 37˚C with a 5% carbon dioxide (CO 2 ) concentration, using a humidified incubator (23). The information of reagents that were used is presented in Table I.…”

Section: Methodsmentioning

confidence: 99%

Quetiapine Significantly Improves the Effectiveness of Radiotherapy in Combating Hepatocellular Carcinoma Progression in a Hep3B Xenograft Mouse Model

YANG,

LIU,

WANG

et al. 2024

In Vivo

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Background/Aim: In hepatocellular carcinoma (HCC) treatment, radiotherapy (RT) stands as a pivotal approach, yet the emergence of radioresistance poses a formidable challenge. This study aimed to explore the potential synergy between quetiapine and RT for HCC treatment. Materials and Methods: A Hep3B xenograft mouse model was used, the investigation tracked tumor progression, safety parameters, and molecular mechanisms. Results: The findings revealed a synergistic anti-HCC effect when quetiapine was coupled with RT that prolonged tumor growth time and a significantly higher growth inhibition rate compared to the

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DNA damage and NF‐κB inactivation implicate glycyrrhizic acid‐induced G ₁ phase arrest in hepatocellular carcinoma cells

Abstract: Tang were the most common herbal medicine prescriptions for significantly reducing overall mortality in patients with liver cancer (Liao et al., 2015). Herbal medicine has been shown as adjunctive therapy to effectively improve quality of life and prolong overall

Cited by 8 publications

References 42 publications

Core–Shell Nanostructured Drug Delivery Platform Based on Biocompatible Metal–Organic Framework-Ligated Polyethyleneimine for Targeted Hepatocellular Carcinoma Therapy

Core–Shell Nanostructured Drug Delivery Platform Based on Biocompatible Metal–Organic Framework-Ligated Polyethyleneimine for Targeted Hepatocellular Carcinoma Therapy

Glycyrrhizic acid inhibits DNA damage repair and enhances cisplatin‐induced apoptosis of melanoma cells

Quetiapine Significantly Improves the Effectiveness of Radiotherapy in Combating Hepatocellular Carcinoma Progression in a Hep3B Xenograft Mouse Model

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DNA damage and NF‐κB inactivation implicate glycyrrhizic acid‐induced G 1 phase arrest in hepatocellular carcinoma cells

Abstract: Tang were the most common herbal medicine prescriptions for significantly reducing overall mortality in patients with liver cancer (Liao et al., 2015). Herbal medicine has been shown as adjunctive therapy to effectively improve quality of life and prolong overall

Cited by 8 publications

References 42 publications

Core–Shell Nanostructured Drug Delivery Platform Based on Biocompatible Metal–Organic Framework-Ligated Polyethyleneimine for Targeted Hepatocellular Carcinoma Therapy

Core–Shell Nanostructured Drug Delivery Platform Based on Biocompatible Metal–Organic Framework-Ligated Polyethyleneimine for Targeted Hepatocellular Carcinoma Therapy

Glycyrrhizic acid inhibits DNA damage repair and enhances cisplatin‐induced apoptosis of melanoma cells

Quetiapine Significantly Improves the Effectiveness of Radiotherapy in Combating Hepatocellular Carcinoma Progression in a Hep3B Xenograft Mouse Model

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DNA damage and NF‐κB inactivation implicate glycyrrhizic acid‐induced G ₁ phase arrest in hepatocellular carcinoma cells