DNA double‐strand breaks caused by new and contemporary endodontic sealers

Abstract

New BioRoot RCS was not toxic whilst Hybrid Root SEAL demonstrated more toxicity and DNA double-strand breaks when compared with other resin- and silicate-based root canal sealers.

Biocompatibility of three new calcium silicate‐based endodontic sealers on human periodontal ligament stem cells

“…Calcium silicate-based endodontic sealers have been recently introduced and shown to produce appropriate biological responses (Eldeniz et al 2016, Prati & Gandolfi 2015. These bioactive sealers represent a new concept in root filling, and their interaction with periapical tissues is considered important (Costa et al 2016).…”

“…Although Endoseal MTA is another type of MTA-based root canal sealer, the composition and particle size of different MTAs are not the same. Recently, Bioroot BC Sealer (Septodont, Saint-Maur-des-Fosses, France) was demonstrated to show good biocompatibility with periodontal ligament cells (Camps et al 2015, Eldeniz et al 2016.…”

A Comparative Chemical Study of Calcium Silicate-Containing and Epoxy Resin-Based Root Canal Sealers

“…Paste B includes silicon dioxide, titanium dioxide, and base resin (pentaerythritol, rosinate, and toluene sulphonamide), and 13.2% set MTA particles as filler. The working time is 23 min, with a complete set time of approximately 2 h. Several properties of this root canal sealer, such as flow and viscosity [10, 11], dimensional change [11], material porosity [12, 13], sealing ability [11], radiopacity, electrical conductivity [14], antibacterial effect [15], biocompatibility [16–20], cytotoxicity [19, 21–23], and genotoxicity [24, 25], have been investigated.…”

“…The BioRoot RCS has a minimum working time of 10 min and a maximum setting time of 4 h. This silicate-based root canal sealer has less toxic effects on human periodontal ligament cells than zinc oxide-eugenol sealer and induces a higher secretion of angiogenic and osteogenic growth factors than ZOE [27]. BioRoot RCS compared to contemporary root canal sealers (AHPlus, Acroseal, EndoRez, RealSeal SE, Hybrid Root SEAL, RootSP, and MTA Fillapex) has the lower cytotoxicity and genotoxicity [24]. The sealing properties of BioRoot RCS combined with gutta-percha are comparable to those of AHPlus, but microCT has revealed a higher void volume for BioRoot RCS than resin-based sealer, possibly due to the shorter working time and less flow than AHPlus [28].…”

When to install the endodontic post? First visit with root canal filling versus a separate second visit for post‐restoration: A randomized controlled trial

“…Several other factors such as the choice of instruments for root canal shaping 7 and root canal sealers for root canal filling 8 are associated with post‐operative pain after root canal treatment. Calcium silicate‐based sealers have been shown to be less cytotoxic 9,10 and promote pulpal 11 and periapical 12 healing. Therefore, they are expected to induce lesser post‐operative pain compared to resin‐based sealers.…”