<scp>DRESS</scp> syndrome developed related to acetylsalicylic acid use

Terlemez, Semiha; Demir, Faruk; Bulut, Yasin; Cartı, Özgür; Gökdoğan, Derviş; Tokgöz, Yavuz; Yenigün, Ayşe

doi:10.1111/pai.12484

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…Kardaun et al have revealed that allopurinol may involve kidney more frequently than carbamazepine. Some case reports have shown that vancomycin induces DRESS syndrome causing renal impairments, cephalosporin induce DRESS syndrome causing hepatic impairment, and NSAIDs induce DRESS syndrome causing hepatic involvement and lymphadenopathy …”

Section: Discussionmentioning

confidence: 97%

Variation of clinical manifestations according to culprit drugs in DRESS syndrome

Sim

Jeong

et al. 2019

Pharmacoepidemiology and Drug

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Purpose Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but serious condition that systematically damages various internal organs through T‐cell–mediated immunological drug reactions. We aimed to investigate whether clinical manifestations of DRESS syndrome differ according to culprit drugs. Methods We retrospectively analyzed data from 123 patients with probable/definite DRESS syndrome based on the RegiSCAR criteria (January 2011 to July 2016). The data were obtained from the Korean Severe Cutaneous Adverse Reaction Registry. Causality was assessed using the World Health Organization‐Uppsala Monitoring Centre criteria. The culprit drugs were categorized as allopurinol, carbamazepine, anti‐tuberculosis drug, vancomycin, cephalosporins, dapsone, and nonsteroidal anti‐inflammatory drugs. Results Differences were observed among culprit drugs regarding the frequencies of hepatitis (P < 0.01), renal dysfunction (P < 0.0001), lymphadenopathy (P < 0.01), and atypical lymphocyte (P < 0.01). Latency period differed among culprit drugs (P < 0.0001), being shorter in vancomycin and cephalosporin. In terms of clinical severity, admission duration (P < 0.01) and treatment duration (P < 0.05) differed among culprit drugs, being longer in vancomycin and anti‐tuberculosis drugs, respectively. Conclusions Based on the findings, clinical manifestations, including latency period and clinical severity, may differ according to culprit drugs in DRESS syndrome.

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Section: Discussionmentioning

confidence: 97%

Variation of clinical manifestations according to culprit drugs in DRESS syndrome

Sim

Jeong

et al. 2019

Pharmacoepidemiology and Drug

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“…Diagnostic criteria are based upon the combination of specific clinical characteristics and laboratory data . Reactivation of viruses such as Epstein‐Barr virus (EBV), human herpesvirus 6 (HHV‐6), and human herpesvirus 7 (HHV‐7) may play a role in stimulating the syndrome with coinciding drug administration …”

Section: Introductionmentioning

confidence: 99%

“…The most commonly implicated drugs in children include antibiotics, namely trimethoprim‐sulfamethoxazole and vancomycin, followed by antiepileptic medications, such as lamotrigine, carbamazepine, and phenytoin . Ibuprofen, nevirapine, raltegravir, acetylsalicylic acid, griseofulvin, fluoxetine, and sulthiamine have been associated triggers in single pediatric case reports . In addition, Sasidharanpillai et al found DRESS to occur more promptly after antibiotic therapy, averaging about one week after drug initiation, compared to over three weeks after antiepileptic therapy …”

Section: Introductionmentioning

confidence: 99%

“…1 Reactivation of viruses such as Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6), and human herpesvirus 7 (HHV-7) may play a role in stimulating the syndrome with coinciding drug administration. 2,3 This entity has been best characterized in adults and is predominately associated with aromatic antiepileptic drugs including phenytoin, phenobarbital, and carbamazepine. 4,5 Understanding of DRESS in children is based upon case reports and small case series.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Ibuprofen, nevirapine, raltegravir, acetylsalicylic acid, griseofulvin, fluoxetine, and sulthiamine have been associated triggers in single pediatric case reports. 3,[26][27][28][29][30][31] In addition, Sasidharanpillai et al found DRESS to occur more promptly after antibiotic therapy, averaging about one week after drug initiation, compared to over three weeks after antiepileptic therapy. 9 Treatment of DRESS is prompt discontinuation of the culprit medication and initiation of systemic corticosteroids to reduce widespread inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Oberlin

Rahnama‐Moghadam

Alomari

et al. 2019

Pediatric Dermatology

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Background Pediatric Drug reaction with eosinophilia and systemic symptoms (DRESS) is an uncommon disease that can be difficult to diagnose. This case series and literature review highlights the clinical features of pediatric DRESS and underscores the differential diagnoses, culprit medications, and need for clinical follow‐up to detect associated autoimmune sequelae. Objective To describe the clinical and laboratory features of pediatric DRESS, identify associated culprit medications, and discuss the natural history of disease. Methods Ten cases of pediatric DRESS were identified in the electronic medical record by searching the inpatient dermatology consultation list at Indiana University between 2013 and 2018. Clinical and laboratory data were collected including demographics, differential diagnoses, culprit medications, resolution of disease, and autoimmune sequelae. Results Pediatric patients with DRESS presented at a mean age of 11.5 years and demonstrated a mean time from drug initiation to onset of symptoms of 4 weeks. The most common inciting drugs included antibiotics (62.5%) followed by antiepileptics (37.5%). Rash and transaminitis resolved by 3 weeks, and 20% of patients, all female, developed autoimmune sequelae including Hashimoto's thyroiditis and an undifferentiated connective tissue disorder and occurred at an average of 14.5 weeks after diagnosis. Limitations This was a small retrospective study of an uncommon clinical diagnosis at a single institution. Conclusions Pediatric DRESS was most commonly caused by antibiotics which are being increasingly recognized in the literature as the predominant culprit medications. The development of autoimmune sequelae is a notable consequence that can present weeks after illness and may preferentially affect female patients.

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DRESS syndrome developed related to acetylsalicylic acid use

Cited by 4 publications

References 11 publications

Variation of clinical manifestations according to culprit drugs in DRESS syndrome

Variation of clinical manifestations according to culprit drugs in DRESS syndrome

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

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