ENIGMA brain injury: Framework, challenges, and opportunities

Abstract

Traumatic brain injury (TBI) is a major cause of disability worldwide, but the heterogeneous nature of TBI with respect to injury severity and health comorbidities make patient outcome difficult to predict. Injury severity accounts for only some of this variance, and a wide range of preinjury, injury-related, and postinjury factors may influence outcome, such as sex, socioeconomic status, injury mechanism, and social support. Neuroimaging research in this area has generally been limited by insufficient sample sizes. Additionally, development of reliable biomarkers of mild TBI or repeated

Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda

“…Participation in the ENIGMA Consortium would also allow access to neuroimaging data across a range of other relevant disorders (e.g. traumatic brain injury) ( Dennis et al, 2020 ).…”

Longitudinal fixel-based analysis reveals restoration of white matter alterations following balance training in young brain-injured patients

“…An important limitation is the relatively small sample size, which hindered our ability to test specific hypotheses regarding the role of specific demographic variables (e.g., age) and injury-related variables (such as age at injury and time since injury) on the gross motor performance changes and training-related structural plasticity changes. Through the ENIGMA pediatric moderate/severe TBI group ( Dennis et al, 2020a , Dennis et al, 2020b ), we aim to improve statistical power to address these open questions (for a paper in preprint, see Dennis et al, 2020a , Dennis et al, 2020b ). Another limitation, which is shared with other current FBA studies, is the heterogeneous nature of TBI lesions.…”

A global collaboration to study intimate partner violence-related head trauma: The ENIGMA consortium IPV working group

“…The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a framework for global collaborative meta-and mega-analysis and has led to some of the largest neuroimaging studies to date, with working groups dedicated to various psychiatric, neurological, and developmental disorders (Hibar et al, 2018;Hoogman et al, 2017;Schmaal et al, 2017). The ENIGMA Brain Injury group was recently created with subgroups based on population type and injury mechanism (Dennis et al, 2020). TBI in the general population is an extremely heterogeneous injury, making it difficult to diagnose, manage, and treat (Millis et al, 2001;Saatman et al, 2008).…”