FADD amplification is associated with CD8+ T‐cell exclusion and malignant progression in HNSCC
Yang Zheng,
Surui Sheng,
Yanni Ma
et al.
Abstract:ObjectiveThis study aimed to clarify the relationship between FADD amplification and overexpression and the tumor immune microenvironment.MethodsImmunohistochemical staining and bioanalysis were used to analyze the association between FADD expression in tumor cells and cells in tumor microenvironment. RNA‐seq analysis was used to detect the differences in gene expression upon FADD overexpression. Flow cytometry and multicolor immunofluorescence staining (mIHC) were used to detect the differences in CD8+ T‐cell… Show more
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