2022
DOI: 10.1002/btpr.3304
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FcγRIIIA affinity chromatography complements conventional functional characterization of rituximab

Abstract: Analytical and functional characterization of batches of biologics/biosimilar products are imperative towards qualifying them for pre-clinical and clinical investigations.Several orthogonal strategies are employed to characterize the functional attributes of these drugs. However, the use of conventional techniques for online monitoring of functional attributes is not feasible. Liquid chromatography is one of the crucial unit operations during the downstream processing of biopharmaceuticals. In this work, we ha… Show more

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