<scp>FcεRI</scp>‐activated basophils express <scp>CCR4</scp>, <scp>CCR8</scp>, <scp>CCR9</scp>, <scp>CCX‐CKR</scp> and <scp>XCR1</scp>

Blom, Lars H.; Bartko, Ewa A.; Møller, Thea K. R.; Poulsen, Lars K.; Jensen, Bettina M.

doi:10.1111/all.15488

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Among the chemokine receptors which basophils are able to express are CCR1, CCR2, CCR3, CXCR2 and CXCR4, and these receptors can be expressed in different combinations dependent on their activation status [42,43]. Basophils express several integrins including Mac-1, VLA-4, and VLA-2 (α 2 β 1 /CD49b CD29), which binds to collagens and other ECM proteins [44].…”

Section: Tissue Recruitment Of Granulocytes During Inflammationmentioning

confidence: 99%

Granulocyte development, tissue recruitment, and function during allergic inflammation

Radtke

Voehringer

2023

Eur J Immunol

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Granulocytes provide a fast innate response to pathogens and allergens. In allergy and anti-helminth immunity, epithelial cells of damaged barriers release alarmins like IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) but also chemokines like CXCL1 or CCL11 to promote cell recruitment and inflammation. In addition, mast cells positioned at barrier tissue sites also quickly release mediators upon specifically sensing antigens through IgE bound to FcεR1 on their surface. Released mediators induce the recruitment of different granulocytes in a timely ordered manner. First, neutrophils extravasate from the blood vasculature to the side of alarmin release and promote a potent inflammatory response. Alarmins and activated mast cells further promote activation of ILC2s and recruitment of basophils and eosinophils, which inhibit neutrophil recruitment and enhance tissue type 2 immunity. In addition to their potent pro-inflammatory effector functions, granulocytes can also contribute to termination and resolution of inflammation. Here, we summarize the development and tissue recruitment of granulocyte subsets, and describe general effector functions and aspects of their increasingly appreciated role in limiting tissue damage. We further discuss targeting approaches for therapeutic interventions in allergic disorders.

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Section: Tissue Recruitment Of Granulocytes During Inflammationmentioning

confidence: 99%

Granulocyte development, tissue recruitment, and function during allergic inflammation

Radtke

Voehringer

2023

Eur J Immunol

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“…The role of CCR4, CCR8, CCR10, and CCR6 or their ligands has been proposed in atopic dermatitis (AD), psoriasis, cutaneous lupus erythematosus, systemic sclerosis, or malignant skin tumors, but not in CU [ 8 , 9 , 10 , 11 ]. In addition, the homing potential of cells can be fine-tuned by scavenger receptors, such as CCX-CKR, which blocks the interaction between ligands and their designated receptors and can be found on activated basophils [ 12 , 13 ]. Lastly, it has been shown that approximately 90% of skin-resident lymphocytes are positive for an adhesion-binding antigen, cutaneous lymphocyte-associated antigen (CLA), which has also been reported on basophils from healthy subjects [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…In an initial study [ 13 ], the expression of a few receptors mentioned above was up-or-down-regulated on basophils from healthy individuals upon anti-IgE stimulation. Therefore, in this study, we sought to broaden the knowledge about the resting expression profile of CU basophils by focusing on chemokine and inflammatory receptors.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the homing potential of cells can be fine-tuned by scavenger receptors, such as CCX-CKR, which blocks the interaction between ligands and their designated receptors and can be found on activated basophils [12,13]. Lastly, it has been shown that approximately 90% of skin-resident lymphocytes are positive for an adhesion-binding antigen, cutaneous lymphocyte-associated antigen (CLA), which has also been reported on basophils from healthy subjects [13].…”

Section: Introductionmentioning

confidence: 99%

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Expression of CCR8 and CCX-CKR on Basophils in Chronic Urticaria Is Amplified by IgE-Mediated Activation

et al. 2023

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Recruitment to the local tissue and alerted phenotype are the hallmarks of basophils in chronic urticaria (CU). Chemokine receptors such as chemokine (C-C motif) receptor 4 (CCR4) or CCR8 have been studied in skin diseases, e.g., atopic dermatitis, but not in CU. In this study, we aimed to define CU’s basophil homing potential and receptor profile and the effect of Omalizumab treatment on these. Unstimulated and activated (anti-IgE, fMLP, C5a, and Substance P) whole blood basophils from 11 Omalizumab-treated CU patients and 10 healthy subjects were investigated with flow cytometry. Unstimulated basophils in CU showed higher expression of the skin-associated (CCR8) and scavenger (CCX-CKR) receptors and lower expression of the lung-associated (CCR3) receptor in contrast to healthy ones. IgE-mediated activation increased the percentage of CCR8 and CCX-CKR in CU compared to healthy group and elevated the expression of the lung-associated chemokine receptor, XCR1, in all groups. A trend of augmented expression of the coagulation cascade (CD87) and fMLP (FPR1) receptors was seen on basophils in CU, while a tendency of reduced expression was seen for itch (IL-31RA) and immunotolerance (CD109) receptors. fMLP and C5a increased the expression of CCR4, CCR8, CCX-CKR, and CD87 and decreased CCR2 and CCR3, though no changes between the groups were found. In conclusion, CU basophils exhibit skin-homing potential amplified by IgE-mediated stimulation.

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Basophils control T cell priming through soluble mediators rather than antigen presentation

Möbs

Salheiser²,

Bleise³

et al. 2023

Front. Immunol.

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Basophils play an important role in the development of type 2 immunity and have been linked to protective immunity against parasites but also inflammatory responses in allergic diseases. While typically classified as degranulating effector cells, different modes of cellular activation have been identified, which together with the observation that different populations of basophils exist in the context of disease suggest a multifunctional role. In this review we aim to highlight the role of basophils play in antigen presentation of type 2 immunity and focus on the contribution basophils play in the context of antigen presentation and T cell priming. We will discuss evidence suggesting that basophils perform a direct role in antigen presentation and relate it to findings that indicate cellular cooperation with professional antigen-presenting cells, such as dendritic cells. We will also highlight tissue-specific differences in basophil phenotypes that might lead to distinct roles in cellular cooperation and how these distinct interactions might influence immunological and clinical outcomes of disease. This review thus aims to consolidate the seemingly conflicting literature on the involvement of basophils in antigen presentation and tries to find a resolution to the discussion whether basophils influence antigen presentation through direct or indirect mechanisms.

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FcεRI‐activated basophils express CCR4, CCR8, CCR9, CCX‐CKR and XCR1

Cited by 5 publications

References 6 publications

Granulocyte development, tissue recruitment, and function during allergic inflammation

Granulocyte development, tissue recruitment, and function during allergic inflammation

Expression of CCR8 and CCX-CKR on Basophils in Chronic Urticaria Is Amplified by IgE-Mediated Activation

Basophils control T cell priming through soluble mediators rather than antigen presentation

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