gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve

Abstract

GPKPDviz is a Shiny application (app) dedicated to real‐time simulation, visualization, and assessment of the pharmacokinetic/pharmacodynamic (PK/PD) models. Within the app, gPKPDviz is capable of generating virtual populations and complex dosing and sampling scenarios, which, together with the streamlined workflow, is designed to efficiently assess the impact of covariates and dosing regimens on PK/PD end points. The actual population data from clinical trials can be loaded into the app for simulation if desired. The app‐generated dosing regimens include single or multiple dosing, and more complex regimens, such as loading doses or intermittent dosing. When necessary, the dosing regimens can be defined externally and loaded to the app for simulation. Using mrgsolve as the simulation engine, gPKPDviz is typically used for population simulation, however, with a slight modification of the mrgsolve model, gPKPDviz is capable of performing individual simulations with individual post hoc parameters, individual dosing logs, and individual sampling timepoints through an external dataset. A built‐in text editor has a debugging feature for the mrgsolve model, providing the same error messages as model compilation in R. GPKPDviz has had stringent validation by comparing simulation results between the app and using mrgsolve in R. GPKPDviz is a member of the suite of Modeling and Simulation Shiny apps developed at Genentech to facilitate the typical modeling work in Clinical Pharmacology. For broader access to the Pharmacometric community, gPKPDviz has been published as an open‐source application in GitHub under the terms of GNU General Public License.

stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments

“…This simulation tool enables users to access specific PK and PD metrics, analyze compartment-specific PK profiles, and compare them with existing data, thereby promoting efficient benchmarking. While other web interfaces have been available providing a valuable support for researchers in a broad set of applications related to PBPK modeling (Chou et al, 2022;Lu et al, 2024;Luyckx, 2024;Vaddady & Kandala, 2021), we focus on TB-specific ADME dynamics and PK/PD metrics in the treatment scenarios.…”

“…ModVizPop is another web app to simulate PK/PD dynamics for compartmental modeling (Vaddady & Kandala, 2021). E-campsis and gPKPDviz are freemium R Shiny apps developed by Calvagone and Genentech, respectively, that allow simulating the PK/PD dynamics with a collection of PK models (Lu et al, 2024;Luyckx, 2024) and the custom integration of thresholds and AUC to be displayed in the plots. Still, there is a need for an opensource unified tool specific to anti-TB PBPK drug analysis.…”