Guillain‐Barre syndrome associated with COVID‐19 infection: A case series

Abstract

In this communication, we reported a series of six patients presented with Guillain-Barré syndrome that associated with COVID-19 infection, which was confirmed with RT-PCR. Here we discuss the laboratory investigation and case management, as well as clinical presentation and outcome of each case. The current report demonstrated the first case series of COVID-19-associated GBS-cases in Sudan.

Guillain-Barre syndrome associated with COVID-19 and malaria coinfection: A case report

“…In this case, the development of GBS could be attributed to the confirmed infections, as both were reported to contribute in GBS manifestation. 1,5,32 The first symptoms of GBS in this case, were lower limb weakness, back pain and paraesthesia. Generalized flaccid paraparesis, or tetraplegia, evolved over a period of one to two days in our patient.…”

“…33 It is the most common cause of acute flaccid paralysis, associated with an antecedent infection, especially viral infections. 4,32 Other causative agents include bacterial infections such as Mycoplasma;Campylobacter jejuni , Haemophilus influenza , andRickettsia rickettsi are well-recognized bacterial agents. 3 Furthermore, GBS has been reported to be associated with parasitic infections including Leishmania donovani , Plasmodium falciparum, and P. vivax.…”

“…5 In Sudan, the diagnosis of GBS is challenging due to the limited resources and diagnostic capacity in the country, therefore, most of physicians relies heavily on the clinical diagnosis. 32 Unfortunately, this implies that many other cases of GBS might have been missed due to the lack of experienced physicians during patients' presentations, particularly in the remote areas of the country.…”

“…17,[27][28][29][30][31] However, cases of GBS recently reported in Sudan were associated with COVID-19 infection. 32 In this communication, we report a case of a 41-year-old female diagnosed with GBS associated with COVID-19 and malaria co-infection in Sudan.…”

Guillain–Barre syndrome associated with hepatitis E virus infection: A case report

“…Guillain‐Barré Syndrome (GBS) is an acute inflammatory disease that affects the peripheral nervous system. It is caused by an aberrant immune response triggered by viral, bacterial, or parasitic infections, a phenomenon known as molecular mimicry 1 . Several infectious agents have been confirmed to be involved in the development of GBS, including but not limited to COVID‐19, hepatitis E and B viruses, malaria, Influenza A virus, as well as major arboviruses like dengue, West Nile, and Zika viruses 1–3 .…”