Hemodynamic analysis of a novel bioresorbable scaffold in porcine coronary artery model

Abstract

Thinner strut Mirage scaffolds induced lower shear stress due to the small size vessels treated as compared to the thick strut version of the Mirage which was implanted in relatively bigger size vessels. Vessel size should be taken into account in planning BRS implantation. Small vessels may not get benefit from BRS implantation even with a streamlined strut profile. This pilot study warrants comparative assessment with commercially available bioresorbable scaffolds.

Influence of microvascular sutures on shear strain rate in realistic pulsatile flow

“…This effect is greatest in sutured simulations when compared to a pristine vessel, and more pronounced with realistic pulsatile flow than a sinusoidal approximation. To date, similar findings have not been reported in the body of literature available, indeed our findings are in contrast to those reported by Tenekecioglu [37,64] when evaluating coronary stent haemodynamics, where no significant difference in endothelial shear rates were seen between steady and pulsatile flows. Similar findings were also reported in a further study evaluating coronary stents [41], although this paper describes timeaveraged values which may influence the conclusion somewhat.…”

“…Although well executed, these studies have not examined the influence of clinically representative sutures at the anastomosis, particularly in the context of realistic pulsatile flows. There have however been studies examining both steady [37] and time-dependent [38,39,40,41] blood flows in other vessels throughout the body. Of particular interest was the work of Perdikaris [39] where a range of approaches to simulating cerebral flows was discussed, including the use of dissipative particle dynamics (DPD) to simulate thrombus formation [42].…”

“…Whilst DPD is beyond the scope of this study, the technique may prove valuable for future work. This also applies to the more recent study by Tenekecioglu [37], where fluid-structural interactions (FSI) were simulated to investigate the shear stress of coronary arterial endothelium when a bioabsorbable stent was in place. The present study, for the first time, describes the process of applying a measured arterial waveform to a realistic sutured microanastomotic geometry, in an attempt to analyse whether the addition of an authentic pulse affects local intravascular haemodynamics.…”