<scp>HCV</scp> in the haemodialysis population: Treat now or later?

Martin, Paul; Jadoul, Michel; Pol, Stanislas

doi:10.1111/jvh.13224

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“…The histopathological spectrum of CKD induced by HCV infection includes membrane-proliferative glomerulonephritis, IgA nephropathy, focal segmental glomerulosclerosis, fibrillary glomerulonephritis, tubulointerstitial nephropathy and thrombotic microangiopathy. The most frequent transmission route of HCV is exposure to infected blood -consequently, hemodialysis patients are at a high risk for infection (23,36), resulting in a higher prevalence of HCV infection than in the general population (37). It has been shown that infection risk increases with the duration of hemodialysis (23,36).…”

Section: Infection With Hcv In Patients On Chronic Hemodialysismentioning

confidence: 99%

Infection with hepatitis C virus in hemodialysis patients: An overview of the diagnosis and prevention rules within a hemodialysis center (Review)

et al. 2020

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Increase in the number of patients with chronic kidney disease (CKD) calls for improved management of these patients. In stage 5 CKD, when the initiation of renal replacement therapy (RRT) becomes necessary, there is an increase in the infection risk of the patients and immunological tests for hepatitis C virus (HCV) detection turn positive at an alarmingly higher rate compared to general population. With the introduction into clinical practice of diagnostic tests, the increased prevalence of HCV among CKD patients has been known since the 1990s. Also, the negative impacts of HCV infection on CKD evolution as well as the unfavorable evolution of grafts received by HCV infected patients are known. Chronic hemodialysis patients are a category of patients whose risk of HCV infection is substantial. Currently, in the hemodialysis centers, at the base of the transmission of HCV infection there are a multitude of factors. Infection with HCV has a different impact on patient with end-stage renal disease (ESRD). Comorbidities in this case have significant sources of mortality and morbidity. It was proven that the post transplantations problems were prevented and mortality was reduced for patients who were diagnosed with HCV and in whom the infection was treated before the kidney transplant (KT). Consequently, early detection of the infection and the application of specific treatment has a considerable impact on the outcome of the patients. Another important component of the management of HCV infection in the chronic hemodialysis patients is the prevention of the infection transmission by applying specific methods. Contents

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