<scp>HOXC</scp>13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription of<scp>CASP</scp>3

Wang, Zhongqiu; Huang, Jianfeng; Yao, Yu; Sun, Qi; Wang, Jie; Shen, Yi; Xu, Lin; Ren, Bingzhong

doi:10.1111/cas.13453

Cited by 27 publications

(20 citation statements)

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“…These differences may be related to the ethnicity of the individuals studied, their lifestyle, diet or other lifestyle factors. Upregulation of HOXC13 has been reported in odontogenic tumors, liposarcoma, metastatic melanoma, esophageal squamous cell carcinoma, lung adenocarcinoma and ameloblastoma (32)(33)(34)(35)(36)(37). However, the expression levels of HOXC13 in CRC was not significantly altered in the present study.…”

Section: Discussionmentioning

confidence: 99%

HOXC10 is significantly overexpressed in colorectal cancer

et al. 2020

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Colorectal cancer (CRC) is one of the most common types of cancer in world and has a high rate of mortality. The majority of cases of CRC are sporadic; however, factors such as age, a family history of inflammatory diseases, diet, lifestyle and genetics increase the risk. HOX genes and lncRNAs are two classes of genes, and alterations in the expression levels of these genes are significantly associated with numerous different types of cancer. In the present study, the expression levels of HOXC10, HOXC-AS3, HOTAIR, HOXC13 and HOXC13-AS in tumor tissues were compared with normal healthy tissues in patients with CRC. Paired tumor and normal tissues were collected from 39 patients with CRC, and reverse transcription-quantitative PCR was used the expression of HOXC-AS3, HOXC13 and HOXC10 in the tumor tissues compared with the respective normal tissues. Expression of these genes were increased in the tumor tissues compared with normal tissues; however, the difference was only significant for HOXC10. Additionally, there was a strong and significant correlation between the expression of HOTAIR and HOXC13, a moderate and significant correlation between the expression of HOTAIR and HOXC13-AS, and between HOXC13 and HOXC13-AS genes. The expression of HOXC10 was significantly higher in tumor tissues compared with the normal tissues; whereas the upregulation of HOXC-AS3 and HOXC13 were not significant. Only the correlation between the expression of HOTAIR and HOXC13 was strong and significant. As HOXC10 expression was significantly upregulated in the tumor tissues relative to normal tissues, it may serve as a biomarker for the diagnosis of CRC and as a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

HOXC10 is significantly overexpressed in colorectal cancer

et al. 2020

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“…HOXC13 is overexpressed in metastatic melanoma tissues compared to primary melanoma tissues and is targeted by miR‐503 in esophageal squamous cell carcinoma. It has been shown that HOXC13 promotes proliferation and inhibits apoptosis of ESCC …”

Section: Discussionmentioning

confidence: 99%

Candidate genes involved in metastasis of colon cancer identified by integrated analysis

et al. 2019

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Colon cancer is one of the most malignant cancers worldwide. Nearly 20% of all colon cancer patients are diagnosed at stage IV (metastasis). However, further study of colon cancer is difficult due to a lack of understanding of its pathogenesis. In this study, we acquired high–throughput sequence data from TCGA datasets and performed integrated bioinformatic analysis including differential gene expression analysis, gene ontology and KEGG pathways analysis, protein–protein analysis, survival analysis, and multivariate Cox proportional hazards regression analysis in order to identify a panel of key candidate genes involved in the metastasis of colon cancer. We then constructed a prognostic signature based on the expression of REG1B, TGM6, NTF4, PNMA5, and HOXC13 which could provide significant prognostic value for colon cancer.

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“…34 Increasing evidence suggests that HOXC13 regulates cell proliferation in several tumors such as lung adenocarcinoma, esophageal squamous cell carcinoma and nasopharyngeal carcinoma. [35][36][37] However, it remains unclear whether HOXC13 regulates the proliferation of AB cells. In the present study, HOXC13 was up-regulated in 26 AB tissues.…”

Section: Discussionmentioning

confidence: 99%

<p>A Novel lncRNA ENST00000512916 Facilitates Cell Proliferation, Migration and Cell Cycle Progression in Ameloblastoma</p>

Sun¹,

Niu²,

Wang³

et al. 2020

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Our purpose was to identify up-regulated long noncoding RNA ENST00000512916 in ameloblastoma (AB) and explore its role in the progression of AB. Methods: We analyzed lncRNA microarray expression profile between six paired AB and normal oral mucosa (NOM) tissues. An up-regulated lncRNA, ENST00000512916 was identified and validated by real-time qPCR. Cell proliferation, migration and cell cycle were detected by CCK-8 assay, transwell chamber and flow cytometry, respectively. Western blotting analysis was used to measure the expression of cell-cycle-related proteins including CyclinD1 and Cyclin-dependent kinase (CDK) 2/4/6. In addition, Xenograft tumor model was constructed to investigate tumor growth. Results: Real-time qPCR confirmed that lncRNA ENST00000512916 was up-regulated in AB tissues. ENST00000512916 knockdown significantly inhibited cell proliferation, migration and the expression of CDK2/4/6 in AM-1 cells. Moreover, ENST00000512916 knockdown suppressed tumor growth in vivo. We also found that ENST00000512916 overexpression significantly promoted the expression of HOXC13 in AM-1 cells. Overexpression of ENST00000512916 promoted cell cycle progression in AM-1 cells, which was reversed by HOXC13 knockdown. Conclusion: Our findings reveal that lncRNA ENST00000512916 promotes cell proliferation, migration and cell cycle progression of AB.

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HOXC13 promotes proliferation of esophageal squamous cell carcinoma via repressing transcription ofCASP3

Cited by 27 publications

References 50 publications

HOXC10 is significantly overexpressed in colorectal cancer

HOXC10 is significantly overexpressed in colorectal cancer

Candidate genes involved in metastasis of colon cancer identified by integrated analysis

<p>A Novel lncRNA ENST00000512916 Facilitates Cell Proliferation, Migration and Cell Cycle Progression in Ameloblastoma</p>

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