Acmella oleracea extract increases collagen content and organization in partially transected tendons

Abstract

Acmella oleracea contains spilanthol as the main active compound, which possesses analgesic and anti‐inflammatory effects that can favor tendon reorganization. To analyze the effect of A. oleracea on the content and organization of collagen in injured tendons, the calcaneal tendon of male Lewis rats was partially transected and treated at the site of injury with a topical application of 20% A. oleracea ointment (AO group) or with the ointment base without the plant extract (B group). The animals were euthanized 21 days after partial transection. Higher collagen concentration was observed in the AO group than in the B group, and morphological analysis using polarization microscopy showed higher birefringence in the AO group than in the B group, indicating higher collagen organization. No difference was observed in the number of fibroblasts, blood vessels, proteoglycan distribution, and maximum load between the B and AO groups. In conclusion, topical application of 20% A. oleracea ointment increased the molecular organization and content of collagen, thus indicating a potential application in tendon repair. Studies on the later phases of the tendon healing process are necessary to demonstrate the possible biomechanical changes after the application of A. oleracea ointment.

A Single-Center Study Evaluating the Effects of a Topical Serum Combining Postbiotics, Peptides, and Botanical Extracts on Skin

“… 9 Theoretically, it may support the native skin microbiome, which has the potential to affect age-related changes in this complex system. Acmella oleracea extract has been shown in preclinical models to improve collagen content and organization following tendon injury 10 and also has both anti-inflammatory and antioxidant activities. 11 Astaxanthin ( H. pluvialis extract) is a potent antioxidant with a unique capacity to quench reactive oxygen species in the cell membrane through inhibition of lipid peroxidation.…”

Skin Ageing: A Progressive, Multi-Factorial Condition Demanding an Integrated, Multilayer-Targeted Remedy

“…Interestingly, Acmella oleracea may also favor tendon repair, via increasing the molecular organization and content of collagen in partially transected tendons. 138 Whether this effect help restore the impaired ECM in aged skin needs further studies.…”

A Review of the Chemistry and Biological Activities of Acmella oleracea (“jambù”, Asteraceae), with a View to the Development of Bioinsecticides and Acaricides

“…Yamane et al showed that jambù helped in collagen deposition and decreased the time of the healing process [ 61 ]. Moreover, de Souza Moro et al demonstrated that A. oleracea increased the molecular organization and content of collagen [ 103 ].…”