Cardiospermum halicacabum in atopic dermatitis: Clinical evidence based on phytotherapic approach

Abstract

Atopic dermatitis is a chronic inflammatory disease that mainly affects children, causing a strong impact on the quality of life. The most affected subjects live in urban areas or in developed countries, with prevalence increased up to 15%-20% in children and from 1% to 3% in adults during the past 30 years. Most adults had the first

Efficacy and Tolerability of a Novel Topical Treatment Containing Pea Protein and Xyloglucan in the Management of Atopic Dermatitis in Children: A Prospective, Multicenter Clinical Study

“…In one randomized controlled study, 55% of subjects treated with aloe vera reported drying up of the skin on test areas while no serious adverse effects were recorded [46]. More recent data showed that aloe vera [47] or Cardiospermum halicacabum [48] based creams exhibit a good efficacy profile. On the other hand, other studies indicated that a prolonged use of topical aloe vera-based products could lead to unwanted side effects such as urticaria [49], contact dermatitis [50][51][52], and widespread dermatitis [53].…”

Antioxidant and Antiinflammatory Effects of Epilobium parviflorum, Melilotus officinalis and Cardiospermum halicacabum Plant Extracts in Macrophage and Microglial Cells

“…For the present research, specific parts of them were selected. In particular, the dried aerial part of Epilobium parviflorum, aerial flower part of Melilotus officinalis, and flowering tops of Cardiospermum halicacabum were chosen based on the richest parts containing bioactive substances [27][28][29]. First of all, we investigated the antioxidant properties of Epilobium parviflorum, Melilotus officinalis, and Cardiospermum halicacabum plants through the DPPH assay.…”

“…: L. MEL1809B and L. CARDI1806L, respectively) were studied. The dried aerial part of Epilobium parviflorum, aerial flower part of Melilotus officinalis, and flowering tops of Cardiospermum halicacabum contain the plants' main active constituents from literature data [27][28][29], were obtained through low-temperature drying. Then, they were shredded and then macerated in 40% v/v ethanol or hot or cold glycerate with euxil 9010, for 21 days, at room temperature, in dark conditions.…”