<scp><i>Chelidonium majus</i></scp>: Relevant safety aspects of a hepatotoxic plant, trawling the web

Maggini, Valentina; Lombardi, Niccolò; Crescioli, Giada; Sivelli, Francesco; Gensini, Gian Franco; Vannacci, Alfredo; Firenzuoli, Fabio

doi:10.1002/ptr.6437

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…Health authorities only guarantee that any forbidden ingredient is listed within the label of the product (Lee et al, 2020; Saldanha et al, 2018). To date, all food supplements worldwide can be sold and bought online, even in countries where they are not currently marketed (Maggini et al, 2019). Healthcare professionals, especially community pharmacists, have a pivotal role in the counselling costumers, in particular with regard to CAM products (Brunelli et al, 2022; Harnett et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports

Crescioli

Maggini

Raschi

et al. 2023

Phytotherapy Research

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The safety of Serenoa repens (SR)‐containing products was evaluated conducting a retrospective worldwide analysis of pharmaco‐ and phytovigilance report forms of suspected adverse reactions (SARs) collected up to 31 January 2022. Multivariate logistic regression was performed to estimate the odds ratios (ORs) of serious SAR. A total of 1810 report forms were analysed; 92% of subjects were males, with a median age of 69 years; 44% of cases were defined as serious. Subjects exposed to dietary supplements had a higher risk of developing serious SARs (OR: 1.60 [95% CI: 1.20–2.15]), as subjects exposed to 2–5 (OR: 1. 83 [95% CI: 1.30–2.58]) or more than 5 (OR: 3.45 [95% CI: 2.36–5.06]) suspect/interacting products. The probability of experiencing serious SAR was higher for subjects exposed to concomitant products (OR: 1.55 [95% CI: 1.15–2.08]), to more than four active compounds (OR: 4.38 [95% CI: 3.21–5.99]) and to SR for more than 14 days (OR: 1.89 [95% CI: 1.10–3, 22]), and lower for subjects exposed to higher doses of SR (OR: of 0.34 [95% CI: 0.20–0.58]). This evidence improves awareness on safety of SR containing products, suggesting the need of a further update of periodic reviews by national and international regulatory agencies.

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Section: Discussionmentioning

confidence: 99%

Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports

Crescioli

Maggini

Raschi

et al. 2023

Phytotherapy Research

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“…In recent years, new technologies are also making an important contribution to active pharmacovigilance. In particular, machine learning, deep learning, and natural language processing approaches can be used to detect adverse reactions from unconventional data sources, e.g., social media [ 16 , 17 ], and to discover safety signals, underlying some adverse reactions not yet reported [ 18 ]. Moreover, safety data collected from healthcare social networks and forums, general social networking, and search logs can be processed by big data sentiment analysis algorithms to provide a more comprehensive picture of the public opinion, experiences, and sentiments about drugs and vaccines [ 19 ], and can be used to create effective public health campaigns on drugs/vaccines safety, diseases prevention or to fight vaccine hesitancy [ 20 ].…”

Section: Pharmacovigilancementioning

confidence: 99%

Pharmacovigilance and Pharmacoepidemiology as a Guarantee of Patient Safety: The Role of the Clinical Pharmacologist

Crescioli

Bonaiuti

Corradetti

et al. 2022

JCM

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“…Celandine herb also contains choline, methylamine, histamine, tyramine, saponin, flavones, vitamin C (up to 180 mg), carotene (up to 10 mg), minerals -silicon, iron, calcium, magnesium, phosphorus, sulfur, chlorine, aluminum, and radioactive potassium. We consider celandine a very effective cholagogue, which, according to some data, has a cytostatic effect, which can be very useful in the case of severe proliferative changes in the mammary glands (Maggini et al 2019).…”

Section: Role Of the Disorders Of The Hepatobiliary System In The Dev...mentioning

confidence: 99%

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

Sokolik

Prozorova

2022

RRP

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Introduction: Fibrocystic breast disease, commonly called fibrocystic breasts or fibrocystic change, is a benign (noncancerous) condition, which is the most common pathology in women of reproductive age. Treatment of fibrocystic breast disease and concomitant pathologies can involve using herbs. Materials and Methods: To make an analysis of literary sources on the development of fibrocystic breast disease in the pathogenesis of diseases of the female reproductive system (clinical human (75%) and animal studies (25%)) were published in the period of 2017–2021. Results and discussion: The diversity of plants in the world is a promising ground for therapeutic improvisation, allowing for an individual approach to each patient, but, most importantly, creates possibilities for maneuvering in the event of ineffectiveness of any means. In some situations, herbal medicine is not only possible or permissible, but strictly mandatory, and is essentially the only effective therapeutic method, which is relatively safe provided the correct selection of combinations and control by a doctor who applies a certain method of phytotherapy, especially given a duration of treatment. The need for a deeper study is long overdue for the pharmacological capabilities of various plant raw materials in the treatment of not only this pathology, but others as well. Conclusion: The development of phytotherapy should be based primarily on scientific developments, but this area can not be considered the prerogative of only phytotherapists, as herbal medicines should be in the arsenal of doctors of all specialties.

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Chelidonium majus: Relevant safety aspects of a hepatotoxic plant, trawling the web

Cited by 4 publications

References 6 publications

Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports

Suspected adverse reactions to medications and food supplements containing Serenoa repens: A worldwide analysis of pharmacovigilance and phytovigilance spontaneous reports

Pharmacovigilance and Pharmacoepidemiology as a Guarantee of Patient Safety: The Role of the Clinical Pharmacologist

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

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