LINC02323 facilitates development of lung squamous cell carcinoma by miRNA sponge and RBP dysregulation and links to poor prognosis

Abstract

Background The poor outcome of patients with lung squamous cell carcinoma (LUSC) highlights the importance of the identification of novel effective prognostic markers and therapeutic targets. Long noncoding RNAs (lncRNAs) have generally been considered to serve important roles in tumorigenesis and the development of various types of cancer, including LUSC. Methods Here, we aimed to investigate the role of LINC02323 in LUSC and its potential mechanisms by performing comprehensive bioinformatic analyses. Results LINC02323 was elevated and positively associated with unfavorable prognosis of LUSC patients. LINC02323 exerted oncogenic function by competitively binding to miR‐1343‐3p and miR‐6783‐3p, thereby upregulating L1CAM expression. Indeed, we also determined that LINC02323 could interact with the RNA‐binding protein DDX3X, which regulates various stages of RNA expression and processing. Conclusion Taken together, we identified that LINC02323 and its indirect target L1CAM can act as novel biomarkers for determining the prognosis of patients with LUSC and thus deserves further study.

CircPRKD3/miR-6783-3p responds to mechanical force to facilitate the osteogenesis of stretched periodontal ligament stem cells

“…With bioinformatics analysis and multiple software predictions, we identified miR-6783-3p as the potential downstream mechanism of circPRKD3. miR-6783-3p was demonstrated to sponge circ_0006427 and LINC02323 to modulate tumor proliferation, migration, and invasion [ 42 , 43 ]. In addition, miR-6783-3p could target CYP2C19 to regulate clopidogrel resistance in patients with cardiovascular diseases [ 44 ].…”

Prognostic implications and biological roles of EMT-related lncRNAs in lung squamous cell carcinoma: an in-depth analysis utilizing a novel prognostic signature and classification system

“…LINC02323 is thought to promote cell growth and migration of ovarian cancer via TGF-β receptor 1 by miR-1343-3p (32). Additionally, Wu et al found that LINC02323 facilitated the development of lung squamous cell carcinoma by miRNA sponge and RNA-binding protein dysregulation, and was linked to poor prognosis (33). lncRNA GPC5-AS1 is believed to stabilize GPC5 mRNA by competitively binding with miR-93/106a to suppress gastric cancer cell proliferation (34).…”