<scp>Imaging‐Guided</scp> Cancer Therapy Based on Multifunctional Magnetic Nanoparticles<sup>†</sup>

Ma, Rong; Hou, Yanglong; Wang, Shuren

doi:10.1002/cjoc.202200857

Cited by 3 publications

(2 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MNPs are used in a wide variety of fields, especially in biomedical applications [ 5 ] ( Figure 1 ). MNPs have demonstrated utility as a medical imaging contrast agent [ 6 , 7 , 8 ], as a carrier for pharmaceutical agents [ 9 , 10 ], and in cancer therapy through magnetically induced hyperthermia (MHT) [ 11 , 12 , 13 ], photodynamic therapy (PDT) [ 6 , 14 , 15 ], and photothermal therapy (PTT) [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…MNPs are used in a wide variety of fields, especially in biomedical applications [5] (Figure 1). MNPs have demonstrated utility as a medical imaging contrast agent [6][7][8], as a carrier for pharmaceutical agents [9,10], and in cancer therapy through magnetically induced hyperthermia (MHT) [11][12][13], photodynamic therapy (PDT) [6,14,15], and photothermal therapy (PTT) [16][17][18]. On the other hand, MNPs have garnered significant interest as valuable tools for in vitro diagnosis with a variety of appealing applications such as trace analysis, magnetic separation, quantitative detection, and rapid testing, making them highly suitable for a range of biomedical uses [19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Recent Applications of Magnetic Nanoparticles in Biomedical Fields

Hong,

Wang,

Zheng

et al. 2024

Materials

View full text Add to dashboard Cite

Magnetic nanoparticles (MNPs) have found extensive application in the biomedical domain due to their enhanced biocompatibility, minimal toxicity, and strong magnetic responsiveness. MNPs exhibit great potential as nanomaterials in various biomedical applications, including disease detection and cancer therapy. Typically, MNPs consist of a magnetic core surrounded by surface modification coatings, such as inorganic materials, organic molecules, and polymers, forming a nucleoshell structure that mitigates nanoparticle agglomeration and enhances targeting capabilities. Consequently, MNPs exhibit magnetic responsiveness in vivo for transportation and therapeutic effects, such as enhancing medical imaging resolution and localized heating at the site of injury. MNPs are utilized for specimen purification through targeted binding and magnetic separation in vitro, thereby optimizing efficiency and expediting the process. This review delves into the distinctive functional characteristics of MNPs as well as the diverse bioactive molecules employed in their surface coatings and their corresponding functionalities. Additionally, the advancement of MNPs in various applications is outlined. Additionally, we discuss the advancements of magnetic nanoparticles in medical imaging, disease treatment, and in vitro assays, and we anticipate the future development prospects and obstacles in this field. The objective is to furnish readers with a thorough comprehension of the recent practical utilization of MNPs in biomedical disciplines.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Recent Applications of Magnetic Nanoparticles in Biomedical Fields

Hong,

Wang,

Zheng

et al. 2024

Materials

View full text Add to dashboard Cite

show abstract

Artificially Engineered Nanoprobes for Ultrasensitive Magnetic Resonance Imaging

Li,

Liu,

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is a noninvasive and radiation‐free technique used for soft tissue. However, there are some limitations of the MRI modality, such as low sensitivity and poor image resolution. Artificially engineered magnetic nanoprobes have been extensively explored as a versatile platform for ultrasensitive MRI contrast agents due to their unique physiochemical characteristics and tunable magnetic properties. In this review, the emphasis is on recent progress in MRI nanoprobes with different structures and elements, including gadolinium‐, iron‐, manganese‐based and metal‐free nanoprobes. The key influencing factors and advanced engineering strategies for modulating the relaxation ratio of MRI nanoprobes are systematically condensed. Furthermore, the widespread and noninvasive visualization applications of MRI nanoprobes for real time monitoring of major organs and accurate disease diagnosing, such as cerebrovascular, ischemia, Alzheimer's disease, liver fibrosis, whole‐body tumors, inflammation, as well as multi‐mode imaging applications are summarized. Finally, the challenges and prospects for the future development of MRI nanoprobes are discussed, and promising strategies are specifically emphasized for improving biocompatibility, precisely engineering of optimal size, AI‐driven prediction and design, and multifunctional self‐assembly to enhance diagnostics. This review will provide new inspiration for artificial engineering and nanotechnology‐based molecular probes for medical diagnosis and therapy with ultrasensitive MRI.

show abstract

Metal Nanoparticles for Simultaneous Use in AC Magnetic Field Hyperthermia and Magnetic Resonance Imaging

Solak,

Atiş,

Kasapoğlu

et al. 2024

J Biomedical Materials Res

View full text Add to dashboard Cite

Magnetic nanoparticles (MNPs) are produced for both diagnosis and treatment due to their simultaneous availability in magnetic resonance imaging (MRI) and magnetic hyperthermia (MHT). Extensive investigations focus on developing MNPs for individual MHT or MRI applications, but the development of MNPs for theragnostic applications has received very little attention. In this study, through efficient examination of synthesis conditions such as metal precursors, reaction parameters, and solvent choices, we aimed to optimize MNP production for effective utilization for MHT and MRI simultaneously. MNPs were synthesized by thermal decomposition under 17 different conditions and deeply characterized by transmission electron microscopy (TEM), x‐ray diffraction (XRD), and x‐ray photoelectron spectroscopy (XPS). The heating efficiency of MNPs under an alternating current (AC) magnetic field was quantified, while MRI performance was evaluated through agar phantom experiments. Our findings highlight the crucial role of benzyl ether in metal ion reduction and size control. Metal‐doped iron oxide MNPs displayed promise for MHT, whereas Mn‐doped iron oxide MNPs exhibited enhanced MRI capabilities. Consequently, five engineered MNPs were considered potential candidates for further studies, demonstrating their dual ability in MRI and MHT.

show abstract

Imaging‐Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles^†

Cited by 3 publications

References 113 publications

The Recent Applications of Magnetic Nanoparticles in Biomedical Fields

The Recent Applications of Magnetic Nanoparticles in Biomedical Fields

Artificially Engineered Nanoprobes for Ultrasensitive Magnetic Resonance Imaging

Metal Nanoparticles for Simultaneous Use in AC Magnetic Field Hyperthermia and Magnetic Resonance Imaging

Contact Info

Product

Resources

About

Imaging‐Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles†

Cited by 3 publications

References 113 publications

The Recent Applications of Magnetic Nanoparticles in Biomedical Fields

The Recent Applications of Magnetic Nanoparticles in Biomedical Fields

Artificially Engineered Nanoprobes for Ultrasensitive Magnetic Resonance Imaging

Metal Nanoparticles for Simultaneous Use in AC Magnetic Field Hyperthermia and Magnetic Resonance Imaging

Contact Info

Product

Resources

About

Imaging‐Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles^†