<scp>In Vivo MRI</scp> Tracking of Degradable Polyurethane Hydrogel Degradation In Situ Using a Manganese Porphyrin Contrast Agent

Tawagi, Eric; Vollett, Kyle D. W.; Szulc, Daniel A.; Santerre, J. Paul; Cheng, Hai‐Ling Margaret

doi:10.1002/jmri.28664

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…Interestingly, a further increase in metal concentration led to a gradual decrease in T1 and T2 times. In a recent study [55], similar values of T1 time decrease were obtained, when manganese porphyrin (MnP) CA was introduced to polyurethane hydrogel to track polyurethane-based implanted biomaterial by MR diagnoses. It has been shown that MnP CA, with a concentration of 4 ppm, in a polyurethane implant reduced It is believed that the r2/r1 ratio defines the type of Cas; a small ratio up to 5 is referred to as positive or T1-Cas and a ratio above 10 is referred to as negative or T2-CAs [54].…”

Section: Mr Performancementioning

confidence: 55%

Manganese-Doped Carbon Dots as a Promising Nanoprobe for Luminescent and Magnetic Resonance Imaging

Stepanidenko,

Vedernikova,

Badrieva

et al. 2023

Photonics

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Luminescent carbon nanodots (CDs) are a low-toxic nanomaterial with a tunable emission in a wide spectral range and with various functional groups on the surface. Therefore, CDs can prospectively serve as luminescent nanoprobes for biomedical applications, such as drug-delivery, visualization, sensing, etc. The doping of CDs with paramagnetic or transition metals allows the expansion of the range of applications of CDs and the fabrication of a multimodal nanoprobe for bioimaging. Here, we developed CDs doped with manganese (Mn) based on commonly used precursors—o-phenylenediamine or citric acid and formamide. The chemical structure, morphology, optical properties, and magnetic resonance responses have been carefully studied. The obtained CDs are up to 10 nm, with emissions observed in the 400–650 nm spectral region. CDs exhibit an ability to reduce both T1 and T2 relaxation times by up to 6.4% and 42.3%, respectively. The high relaxivity values suggest the use of CDs as promising dual-mode contrast agents for T1 and T2 MRI. Therefore, our developed CDs can be utilized as a new multifunctional nanoscale probe for photoluminescent and magnetic resonance bioimaging.

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Section: Mr Performancementioning

confidence: 55%

Manganese-Doped Carbon Dots as a Promising Nanoprobe for Luminescent and Magnetic Resonance Imaging

Stepanidenko,

Vedernikova,

Badrieva

et al. 2023

Photonics

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“…resorption) over time, demonstrating the potential of the investigated technique for in vivo tracking of degradable polyurethane-based biomaterial with MnPenhanced MRI, with no histopathology-revealed toxicity and less than 2% Mn ion release over 28 days. 8 This work advances our understanding of the efficacy and safety of MnPs as labeling contrast agents for noninvasive tracking of implanted biomaterials in vivo.…”

mentioning

confidence: 90%

“…The article by Tawagi et al specifically presented a class of MnPs containing a covalent binding site for pairing to polymers. In vitro and in vivo MRI‐based assessment of the MnP‐labeled hydrogels was performed and compared with unlabeled hydrogels 8 . Tawagi et al showed that covalently labeling hydrogels with MnPs led to a significant reduction in T1 relaxation times in vitro.…”

mentioning

confidence: 99%

“…In this issue of JMRI, Tawagi et al have investigated MnPs as T1 contrast agents for quantitative in vivo tracking of degradable polyurethane hydrogels on 3.0 T MRI. 8 The article by Tawagi et al specifically presented a class of MnPs containing a covalent binding site for pairing to polymers. In vitro and in vivo MRI-based assessment of the MnPlabeled hydrogels was performed and compared with unlabeled hydrogels.…”

mentioning

confidence: 99%

“…In vitro and in vivo MRI-based assessment of the MnPlabeled hydrogels was performed and compared with unlabeled hydrogels. 8 Tawagi et al showed that covalently labeling hydrogels with MnPs led to a significant reduction in T1 relaxation times in vitro. Moreover, this study showed that MnP-labeled implants were clearly distinguishable from surrounding tissues and fluids in vivo and that T1 values of the labeled implants significantly increased from 1 to 7 weeks following dorsal implantation in a rat model.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Editorial for “In Vivo MRITracking of Polyurethane Hydrogel DegradationIn SituUsing a Manganese Porphyrin Contrast Agent”

Alhamami

Daye

2023

Magnetic Resonance Imaging

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A review of biomaterial degradation assessment approaches employed in the biomedical field

Mndlovu,

Kumar,

du Toit

et al. 2024

npj Mater Degrad

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The biological response to biomaterials plays a crucial role in selecting suitable materials for the formulation and development of tissue engineering platforms. Biodegradation is one of the properties that is considered in selecting appropriate biomaterials for biomedical applications. Biodegradation is the process of breaking down large molecules into smaller molecules with/without the aid of catalytic enzymes. The biodegradation process is crucial in the chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) process of biomaterials and small molecules in the body. Degradation of biomaterials can be followed by assessing the physical, mechanical, and chemical attributes of biomaterials. There are several techniques/parameters that can be targeted when studying the degradation of biomaterials, with gravimetric analysis, surface erosion, and morphological changes being the largely employed techniques. However, the techniques present a few limitations, such as technical errors and material solubility being mistaken for degradation, and these techniques can infer but not confirm degradation as they do not provide the chemical composition of fragmenting/fragmented molecules. The American Society for Testing and Materials (ASTM) guidelines provide techniques and parameters for assessing biodegradation. However, the ASTM guidelines for degradation assessment approaches and techniques need to be updated to provide sufficient evidence to draw conclusive decisions regarding the degradation of biomaterials. In this review, the degradation assessment approaches and techniques are critically reviewed about their advantages and disadvantages, and to provide suggestions on how they can still play a role in assessing the degradation of biomaterials. This review could assist researchers employ cost-effective, efficient, and multiple degradation assessment techniques to evaluate and provide sufficient information about the degradation of biomaterials. Suggested future ASTM guidelines for assessing biodegradation should include measuring parameters (such as chemical, mechanical, or physical attributes of biomaterials) in real-time, employing non-invasive, continuous, and automated processes.

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In Vivo MRI Tracking of Degradable Polyurethane Hydrogel Degradation In Situ Using a Manganese Porphyrin Contrast Agent

Cited by 6 publications

References 28 publications

Manganese-Doped Carbon Dots as a Promising Nanoprobe for Luminescent and Magnetic Resonance Imaging

Manganese-Doped Carbon Dots as a Promising Nanoprobe for Luminescent and Magnetic Resonance Imaging

Editorial for “In Vivo MRITracking of Polyurethane Hydrogel DegradationIn SituUsing a Manganese Porphyrin Contrast Agent”

A review of biomaterial degradation assessment approaches employed in the biomedical field

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