2013
DOI: 10.1002/wrna.1202
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IRES mediated translational regulation of p53 isoforms

Abstract: p53 is a well known tumor suppressor protein that plays a critical role in cell cycle arrest and apoptosis. It has several isoforms which are produced by transcriptional and posttranscriptional regulatory mechanisms. p53 mRNA has been demonstrated to be translated into two isoforms, full-length p53 (FL-p53) and a truncated isoform ΔN-p53 by the use of alternative translation initiation sites. The mechanism of translation regulation of these two isoforms was further elucidated by the discovery of IRES elements … Show more

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Cited by 36 publications
(41 citation statements)
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References 75 publications
(139 reference statements)
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“…Some of the well-characterized ITAFs are human antigen R (HuR), La autoantigen, programed cell death 4 (PDCD4), polypyrimidine tract binding (PTB) protein, heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), hnRNAC1/C2 upstream of NRAS (UnR), nuclear factor 45 (NF45), insulinlike growth factor 2-binding protein 1 (IGF2BP1), Y-box protein 1 (YB1), and poly(C) binding protein (PCBP) [20,49,50]. The levels, activity, and localization of these ITAFs are regulated by various signaling pathways, which in turn regulate the IRES-mediated translation.…”
Section: Ires Trans-acting Factors Regulating Ires-mediated Translationmentioning
confidence: 99%
“…Some of the well-characterized ITAFs are human antigen R (HuR), La autoantigen, programed cell death 4 (PDCD4), polypyrimidine tract binding (PTB) protein, heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), hnRNAC1/C2 upstream of NRAS (UnR), nuclear factor 45 (NF45), insulinlike growth factor 2-binding protein 1 (IGF2BP1), Y-box protein 1 (YB1), and poly(C) binding protein (PCBP) [20,49,50]. The levels, activity, and localization of these ITAFs are regulated by various signaling pathways, which in turn regulate the IRES-mediated translation.…”
Section: Ires Trans-acting Factors Regulating Ires-mediated Translationmentioning
confidence: 99%
“…The D133TP53 transcript also encodes the D160p53 protein, which lacks the first 160 amino acids generated by alternative initiation of translation (10). In addition, internal ribosome entry site (IRES)-mediated translation of TP53 mRNA leads to expression of the D40p53 isoforms (35). Of note, there are two sets of transcripts capable of encoding both full-length (FL)/D40TP53_T1 and FL/D40TP53_T2, differ by only three nucleotides in their length, due to the incorporation of CAG at the intron exon junction of exon 2 (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Translation of cellular mRNA can likewise be mediated via initiation at cellular IRESs during many physiological and pathological stress conditions, as exemplified by p53 IRESs (Graber & Holcik, 2007;Komar & Hatzoglou, 2011;Sharathchandra et al, 2014) used in this study (Figs 5 and 6). RNA structures and canonical initiation factors/ITAFs involved in IRES-driven translation initiation appear to vary for IRESs in cellular and viral mRNA (Komar & Hatzoglou, 2011;Niepmann, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…We also investigated whether IDR can inhibit the cellular IRES-mediated translation. Two cellular p53 IRESs, IRES (1 and 2) and IRES (2), were shown to regulate the translation of full-length p53 and a truncated isoform p53, respectively (Graber & Holcik, 2007;Sharathchandra et al, 2014). Therefore, a dicistronic reporter construct with p53 IRES (1 and 2) was also generated.…”
Section: Mechanism-of-action Of Idrmentioning
confidence: 99%