2023
DOI: 10.1111/iej.14001
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IWP‐2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro

Ajjima Chansaenroj,
Chatvadee Kornsuthisopon,
Ravipha Suwittayarak
et al.

Abstract: AimTo investigate the effect of IWP‐2, Wnt inhibitor, on human dental pulp stem cells (hDPSCs) responses.MethodologyhDPSCs were isolated from human dental pulp tissues. Cells were treated with 25 μM IWP‐2 for 24 h, and subsequently, the gene expression profile was examined using high‐throughput RNA sequencing. The mRNA expression was analysed using qPCR. The effect of IWP‐2 was investigated in both normal and LPS‐induced hDPSCs (inflamed hDPSCs). CD4+ T cells and CD14+ monocyte‐derived macrophages were culture… Show more

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