1991
DOI: 10.1002/bip.360310207
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L‐Alanyl‐L‐alanyl‐L‐alanine: Parallel pleated sheet arrangement in unhydrated crystal structure, and comparisons with the antiparallel sheet structure

Abstract: The tripeptide L-alanyl-L-alanyl-L-alanine has been crystallized from a water/dimethylformamide solution in an unhydrated form, with cell dimensions a = 11.849, b = 10.004, c = 9.862 A, beta = 101.30 degrees, monoclinic space group P21 with 4 molecules per cell (2 independent molecules in the asymmetric unit). The structure was determined by direct methods and refined to a discrepancy index R = 0.057. The tri-L-alanine molecules are packed in a parallel pleated sheet arrangement with unusually long amide nitro… Show more

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Cited by 37 publications
(71 citation statements)
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“…The geometric parameters [2,3] of the oxygen atoms in the A and B molecules for the two tri-peptides are summarized in Fig. 3.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…The geometric parameters [2,3] of the oxygen atoms in the A and B molecules for the two tri-peptides are summarized in Fig. 3.…”
Section: Resultsmentioning
confidence: 99%
“…The B3LYP exchange-correlation functional was employed and the 6-311G(d,p) basis set was used. Atomic coordinates obtained from X-ray diffraction experiments were used as input for the two b-sheet structure calculations [2,3]. Six molecules (3 · 2) were used for the parallel b-sheet calculation, and eight molecules (4 · 2) were used for the anti-parallel bsheet calculation (see Fig.…”
Section: Dft Calculationmentioning
confidence: 99%
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“…However, these studies are all done in presence of water of hydration. The structure of these types of peptides in the absence of substantial water has been shown to be beta-sheets which is consistent both with fiber X-ray diffraction studies and with bound water determination for the silk fibers (unpublished data) [23].…”
Section: Proposed Structurementioning
confidence: 57%