<scp>l</scp>-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism<i>via</i>heat shock factor 1

Lin, Ling; Han, Shijie; Gong, Zhihua; Ding, Feng; Z, Liu; Xiao, Wenjun

doi:10.1039/d3fo01001e

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…In this experiment, HSP27, HSP70, HSP90, and HSPH1 were upregulated in the HS group, while their expression was downregulated after LTA intervention. This is consistent with previous research findings 51 . HSPH1, also known as HSP105, can modulate the activity of HSP70 by forming a complex with it, which in turn affects the function of HSP70 52 .…”

Section: Discussionsupporting

confidence: 93%

L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

Liu,

Wang,

Lin

et al. 2023

J Sci Food Agric

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BACKGROUNDHeat stress (HS) damages the intestines, disrupting gut microbiota and immune balance. l‐Theanine (LTA), found in tea, alleviates oxidative stress and cell apoptosis under HS; however, its effects on gut microbiota and immunity under HS remain unclear. To investigate this, we administered LTA doses of 100, 200, and 400 mg·kg−1·d−1 to C57BL/6J mice. On day 44, the model group and LTA intervention group were subjected to continuous 7‐day HS treatment for 2 h per day.RESULTSThe results demonstrated that LTA intervention improved food intake, body weight, and intestinal epithelium, and reduced the water intake of heat‐stressed mice. It increased the abundance of Turicibacter, Faecalibaculum, Bifidobacterium, and norank_f_Muribaculaceae, while reducing that of Lachnoclostridium and Desulfovibrio. LTA intervention also increased the concentrations of amino acid and lipid metabolites, regulated macrophage differentiation stimulated by gut microbiota and metabolites, reduced the antigen presentation by macrophages to the specific immune system, promoted B‐cell differentiation and sIgA secretion, inhibited pro‐inflammatory factors, and enhanced intestinal defense. Mechanistically, LTA downregulated heat shock protein 70 expression and the TLR4/NF‐κB/p38 MAPK signaling pathway, restoring gut microbiota and immune balance.CONCLUSIONWe suggest that LTA can alleviate HS by modulating gut microbiota, metabolites, and immunity, indicating its potential as a natural active ingredient for anti‐HS food products. © 2023 Society of Chemical Industry.

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Section: Discussionsupporting

confidence: 93%

L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

Liu,

Wang,

Lin

et al. 2023

J Sci Food Agric

Self Cite

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Fibroblast growth factor 20 ameliorates cardiac hypertrophy via activation ErbB2

Chen,

Zhou,

Wang

et al. 2024

Heliyon

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L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response

García-Niño,

Correa,

Zúñiga-Muñoz

et al. 2024

Toxicology and Applied Pharmacology

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l-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolismviaheat shock factor 1

Abstract: Extreme heat caused by global warming accelerated the frequency of heat stress (HS). Proteotoxic stress induced by aggregation of misfolded proteins and metabolic stress triggered by alterations in the metabolism...

Cited by 4 publications

References 47 publications

L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

L‐Theanine alleviates heat stress through modulation of gut microbiota and immunity

Fibroblast growth factor 20 ameliorates cardiac hypertrophy via activation ErbB2

L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response

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