<scp>Long‐acting</scp>
            contraception in adolescents and young women with type 1 and type 2 diabetes

Salinas, Andrea; Merino, Paulina M.; Giraudo, Franco; Codner, Ethel

doi:10.1111/pedi.13069

Cited by 14 publications

(19 citation statements)

References 67 publications

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“…Moreover, PwT1D frequently used condoms or a combined oral contraceptive as a single method, which have shown an unacceptably high failure rate in adolescents. 28 On the other hand, long-acting reversible contraception, which is considered the most efficient pregnancy prevention method and does not depend on the user's compliance, was rarely used. 28 Moreover, in PwT1D increasing HbA1c was associated with a higher odds of ever reporting sexual activity without protection.…”

Section: Discussionmentioning

confidence: 99%

“…This combination was scarcely used in both groups. Moreover, PwT1D frequently used condoms or a combined oral contraceptive as a single method, which have shown an unacceptably high failure rate in adolescents 28 . On the other hand, long‐acting reversible contraception, which is considered the most efficient pregnancy prevention method and does not depend on the user's compliance, was rarely used 28 …”

Section: Discussionmentioning

confidence: 99%

“…28 On the other hand, long-acting reversible contraception, which is considered the most efficient pregnancy prevention method and does not depend on the user's compliance, was rarely used. 28 Moreover, in PwT1D increasing HbA1c was associated with a higher odds of ever reporting sexual activity without protection.…”

Section: Discussionmentioning

confidence: 99%

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Risky sexual behaviors in adolescents and young adult women with type 1 diabetes: An overlooked problem

et al. 2021

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The presence of unprotected sex activity in women living with type 1 diabetes (T1D) who have insufficient glycemic control should be considered as a specific risky behavior. To evaluate risky behaviors, including unprotected sexual activity, sources of information and knowledge related to reproductive health in adolescents and young adult women with T1D (PwT1D) compared to a group of adolescents and young adult women without diabetes (Comparison group). PwT1D and the Comparison group completed a questionnaire with validated measures that assessed reproductive health. PwT1D (n = 115, age = 17.7 ± 3.2 years) and Comparison group (n = 386, age = 18.3 ± 2.9) were recruited. The proportion of women reporting having sex without any contraceptive was similar in both groups (57.1% and 50%, in PwT1D and Comparison group, respectively). The use of non‐effective contraceptive was reported in 63.2% and 63.6% of the PwT1D and Comparison group, respectively. Among PwT1D, parents, formal sex education, and friends were the primary source of information on reproductive health. Low levels of knowledge about diabetes and pregnancy were observed in PwT1D. HbA1c level was associated with having at least one sexual activity without any contraception (OR = 1.63, p = 0.039). PwT1D have similar rates of risky behaviors compared to a Comparison group. Sexual risky behaviors should be especially considered in PwT1D with glycemic control above the optimal level. Parents are an important source of reproductive health information for PwT1D. Use of effective contraception should be reinforced in sexually active PwT1D.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risky sexual behaviors in adolescents and young adult women with type 1 diabetes: An overlooked problem

et al. 2021

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“…Long-term ENG use does not lead to significant weight gain in adolescents [158]; furthermore, it does not negatively affect cardiovascular risk and metabolic profile [100]. The ENG release implant is a safe and effective system in adolescents with cardiovascular conditions [159], such as in young girls with PCOS [157] or diabetes [160]. Thus, in young persons, ease of use, high efficacy, and high acceptability make the ENG contraceptive implant an important choice to prevent undesired pregnancy [161].…”

Section: Contraceptive Implant In Adolescent Girlsmentioning

confidence: 99%

Safety and Benefits of Contraceptives Implants: A Systematic Review

et al. 2021

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Progestin-only contraceptive implants provide long-acting, highly effective reversible contraception. We searched the medical publications in PubMed, CENTRAL, and EMBASE for relevant articles on hormonal implants published in English between 1990 and 2021. Levonorgestrel (LNG) 6-capsule subdermal implants represented the first effective system approved for reversible contraception. The etonogestrel (ENG) single rod dispositive has been widely employed in clinical practice, since it is a highly effective and safe contraceptive method. Abnormal menstrual bleeding is a common ENG side effect, representing the main reason for its premature discontinuation. Emerging evidence demonstrated that it is possible to extend the use of the ENG implant beyond the three-year period for which it is approved. The ENG implant could be an effective and discrete alternative to the IUD in young girls, such as post-partum/post-abortion. Implants should be inserted by trained skilled clinicians who previously provide adequate counselling about their contraceptive effect, benefits, and any possible adverse events. More studies are needed to validate the extended use of the ENG implant for up to 5 years.

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“…In addition to the treatment of above-mentioned diseases, LAPFs also have proven effective for contraception. Long-acting reversible contraceptives are recommended as first-line contraceptives for adolescents and young women 8 . Long-acting hormonal contraceptives with great efficacy and relative ease of use are widely accepted by millions of women with a variety of options 9 , 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

Shi

Wang

et al. 2021

Acta Pharmaceutica Sinica B

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The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations (LAPFs) with the aim of improving drug pharmacokinetics and therapeutic efficacy. LAPFs have been proven to extend the half-life of therapeutics, as well as to improve patient adherence; consequently, this enhances the outcome of therapy positively. Over past decades, considerable progress has been made in designing effective LAPFs in both preclinical and clinical settings. Here we review the latest advances of LAPFs in preclinical and clinical stages, focusing on the strategies and underlying mechanisms for achieving long acting. Existing strategies are classified into manipulation of in vivo clearance and manipulation of drug release from delivery systems, respectively. And the current challenges and prospects of each strategy are discussed. In addition, we also briefly discuss the design principles of LAPFs and provide future perspectives of the rational design of more effective LAPFs for their further clinical translation.

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Long‐acting contraception in adolescents and young women with type 1 and type 2 diabetes

Cited by 14 publications

References 67 publications

Risky sexual behaviors in adolescents and young adult women with type 1 diabetes: An overlooked problem

Risky sexual behaviors in adolescents and young adult women with type 1 diabetes: An overlooked problem

Safety and Benefits of Contraceptives Implants: A Systematic Review

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

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