Encyclopedia of Life Sciences 2007
DOI: 10.1002/9780470015902.a0005972.pub2
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m RNA Stability and the Control of Gene Expression

Abstract: Messenger ribonucleic acid (mRNA) stability is a principal determinant of gene expression; intrinsic stabilities of mammalian mRNAs can differ by more than 100‐fold, and the stability of an mRNA species can be altered markedly by developmental, cell cycle and environmental stimuli. The determinants of mRNA stability and the pathways by which they function are diverse and are represented by a spectrum of informative model systems.

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Cited by 3 publications
(4 citation statements)
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“…group ( Figure 2C , Lower Panel), while the mRNA levels of each Top4 destabilized genes were substantially increased in the Diff. group ( Figure 2D , Lower Panel), which is counterintuitive to the known relation between mRNA half-life and mRNA expression 22 .…”
Section: Resultsmentioning
confidence: 67%
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“…group ( Figure 2C , Lower Panel), while the mRNA levels of each Top4 destabilized genes were substantially increased in the Diff. group ( Figure 2D , Lower Panel), which is counterintuitive to the known relation between mRNA half-life and mRNA expression 22 .…”
Section: Resultsmentioning
confidence: 67%
“…It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted September 22, 2023. ; https://doi.org/10.1101/2023.09. 22.558981 doi: bioRxiv preprint nonsense-mediated decay (NMD) pathway. These mechanisms establish mRNA decay networks in which mRNA stability is genetically programmed, tunable, and tightly regulated.…”
Section: Introductionmentioning
confidence: 99%
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“…groups, Venn Diagram displayed the enormous percentage of overlapping MSGs (58.6%) and LSGs (71.4%) between Diff. and Undiff., which could be recognized as gene sets maintaining fundamental cell activities and metabolisms (Figure 3B) 18 . Herein, to clearly elucidate the divergence of mRNA stability between Diff.…”
Section: Transcriptome-wide Mrna Stability Profiling Of Differentiated Sh-sy5y Cellsmentioning
confidence: 99%