2024
DOI: 10.1002/pro.5170
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MeCP2 is a naturally supercharged protein with cell membrane transduction capabilities

Alexander V. Beribisky,
Anna Huber,
Victoria Sarne
et al.

Abstract: The intrinsically disordered protein MeCP2 is a global transcriptional regulator encoded by the MECP2 gene. Although the structured domains of MeCP2 have been the subject of multiple studies, its unstructured regions have not been that extensively characterized. In this work, we show that MeCP2 possesses properties akin to those of supercharged proteins. By utilizing its unstructured portions, MeCP2 can successfully transduce across cell membranes and localize to heterochromatic foci in the nuclei, displaying … Show more

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