2022
DOI: 10.1002/cjoc.202200191
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Monoribbed‐Functionalized Macrobicyclic Iron(II) Complexes Decorated with Terminal Reactive and Vector Groups: Synthetic Strategy, Chemical Transformations and Structural Characterization

Abstract: General and straightforward synthetic strategy towards the iron(II) clathrochelates with functionalizing substituents in their apical capping and one of the three chelate ribbed fragments was developed. Their hexachloroclathrochelate precursors were prepared by the direct template condensation of dichloroglyoxime with a suitable boronic acid on the Fe 2+ ion as a matrix and underwent a stepwise nucleophilic substitution with S 2 -, N 2 -or O 2 -bis-nucleophiles, forming the alicyclic or aromatic N 2 -, S 2 -or… Show more

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Cited by 4 publications
(1 citation statement)
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“…This hampered an ability to introduce various vector and biorelevant (including anisole) groups into their caging or bis-caging ligands for a target delivery of their metal complexes, as the probable bioeffectors, to a given biosystem, thus improving their bioactivity. Therefore, we recently developed [12] a general synthetic approach that allowed to obtain the metal clathrochelates with functionalizing substituents or groups both in their ribbed chelate α-dioximate moieties and in their apical cross-linking fragments as well. However, these substituents(groups) are typically reactive and, therefore, they can undergo their unwanted chemical transformations or side reactions in a course of the multistep preparation of the target clathrochelate complex of a given symmetry and an improved functionality; the presence of these terminal polar groups can also hamper its chromatographic isolation.…”
Section: Introductionmentioning
confidence: 99%
“…This hampered an ability to introduce various vector and biorelevant (including anisole) groups into their caging or bis-caging ligands for a target delivery of their metal complexes, as the probable bioeffectors, to a given biosystem, thus improving their bioactivity. Therefore, we recently developed [12] a general synthetic approach that allowed to obtain the metal clathrochelates with functionalizing substituents or groups both in their ribbed chelate α-dioximate moieties and in their apical cross-linking fragments as well. However, these substituents(groups) are typically reactive and, therefore, they can undergo their unwanted chemical transformations or side reactions in a course of the multistep preparation of the target clathrochelate complex of a given symmetry and an improved functionality; the presence of these terminal polar groups can also hamper its chromatographic isolation.…”
Section: Introductionmentioning
confidence: 99%