<scp>MRI</scp><scp>CEST</scp> at 1<scp>T</scp> with large µeff<scp>L</scp>n3+ complexes <scp>T</scp> m3+‐<scp>HPDO</scp>3<scp>A</scp>: An efficient <scp>MRI</scp> p<scp>H</scp> reporter

Rancan, Giaime; Castelli, Daniela Delli; Aime, Silvio

doi:10.1002/mrm.25589

Cited by 19 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complexes of L1 and L2 were prepared by following previously described procedures. [ 26,24,20,14,7, À2, À15, À19, À20, À34, À37 ppm;E SI-MS: m/z (%): 242.2 (100) [M/2] 2 + .…”

Section: Methodsmentioning

confidence: 99%

“…[27] Using paraSHIFTagents requires the acquisition of af ull spectrum on the MRI scanner and needs somewhat higher concentrationsf or in vivo studies in comparison to paraCEST agents. [26,27] The amide appended-complexess tudied here however, with the exceptiono f[ Co(L1)] 2 + ,a re not suitable as paraSHIFT agents because their non-exchangeable macrocyclic protonsa re broadened due to dynamic processes. Studies of Co II and Fe II complexes containing rigid aromatic pendent groups [2c,d, 8] that produce suitable NMR spectra for paraSHIFT applicationsare underway.…”

Section: Thermometrymentioning

confidence: 98%

See 1 more Smart Citation

Six, Seven or Eight Coordinate Fe^II, Co^II or Ni^II Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry

Olatunde

Bond

Dorazio

et al. 2015

Chemistry A European J

View full text Add to dashboard Cite

FeII, CoII and NiII complexes of two tetraazamacrocycles (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane (L1) and 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane (L2) show promise as paraCEST agents for registration of temperature (paraCEST = paramagnetic Chemical Exchange Saturation Transfer). The FeII, CoII and NiII complexes of L1 show up to four CEST peaks shifted ≤ 112 ppm, whereas analogous complexes of L2 show only a single CEST peak at ≤ 69 ppm. Comparison of the temperature coefficients (CT) of the CEST peaks of [Co(L2)]2+, [Fe(L2)]2+, [Ni(L1)]2+ and [Co(L1)]2+ showed that a CEST peak of [Co(L1)]2+ gave the largest CT (−0.66 ppm/°C at 4.7 T). NMR spectral and CEST properties of these complexes correspond to coordination complex symmetry as shown by structural data. The [Ni(L1)]2+ and [Co(L1)]2+ complexes have a six-coordinate metal ion bound to the 1-, 4- amide oxygens and four nitrogens of the tetraazamacrocycle. The [Fe(L2)]2+ complex has an unusual eight-coordinate FeII bound to four amide oxygens and four macrocyclic nitrogens. For [Co(L2)]2+, one structure has seven-coordinate CoII with three bound amide pendents and a second structure has a six-coordinate CoII with two bound amide pendents.

show abstract

“…Complexes of L1 and L2 were prepared by following previously described procedures. [ 26,24,20,14,7, À2, À15, À19, À20, À34, À37 ppm;E SI-MS: m/z (%): 242.2 (100) [M/2] 2 + .…”

Section: Methodsmentioning

confidence: 99%

Section: Thermometrymentioning

confidence: 98%

Six, Seven or Eight Coordinate Fe^II, Co^II or Ni^II Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry

Olatunde

Bond

Dorazio

et al. 2015

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…In a recent study using Yb 3+ -HPDO3A, it was shown that tumor pHe mapping can also provide information about tumor aggressiveness in a rat glioma model [97]. The advantage of PARACEST agents endowed with highly shifted resonances is further witnessed in the case of Tm 3+ -HPDO3A pH-sensitive agent, which allows in vivo tumor pH mapping at lower magnetic fields (1 T), due to the far-shifted hydroxyl resonances of the two diastereoisomers (71 and 185 ppm, respectively) [98]. PARACEST agents possessing two sets of exchangeable protons in the same structure were also investigated by Pagel's group who reported that, in Yb 3+ DO3A-oAA, a complex containing both amide and aryl amine protons, the formation of intramolecular hydrogen bond with a proximal carboxylate ligand resulted in a reduction of the amine exchange rate, thus generating a second CEST effect [99].…”

Section: Paramagnetic Ph-responsive Probes (Paracest)mentioning

confidence: 99%

Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

Anemone

Consolino

Arena

et al. 2019

Cancer Metastasis Rev

122

110

View full text Add to dashboard Cite

Cancer cells are characterized by a metabolic shift in cellular energy production, orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation to increased glycolysis, regardless of oxygen availability (Warburg effect). The constitutive upregulation of glycolysis leads to an overproduction of acidic metabolic products, resulting in enhanced acidification of the extracellular pH (pHe~6.5), which is a salient feature of the tumor microenvironment. Despite the importance of pH and tumor acidosis, there is currently no established clinical tool available to image the spatial distribution of tumor pHe. The purpose of this review is to describe various imaging modalities for measuring intracellular and extracellular tumor pH. For each technique, we will discuss main advantages and limitations, pH accuracy and sensitivity of the applied pH-responsive probes and potential translatability to the clinic. Particular attention is devoted to methods that can provide pH measurements at high spatial resolution useful to address the task of tumor heterogeneity and to studies that explored tumor pH imaging for assessing treatment response to anticancer therapies.

show abstract

“…As was shown in the kidney imaging studies, paraCEST agents such as Yb‐HPDO3A (Figure (d)) and Yb‐DO3A‐OAA, Tm‐DOTAM‐Gly‐Lys can be used to produce high resolution pH maps which should be of interest for monitoring tumors . Silvio Aime and colleagues have extended their agent studies into tumor pH mapping .…”

Section: Cest Mri Ph Imaging Applicationsmentioning

confidence: 99%

pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI

Pavuluri

McMahon

2017

Israel Journal of Chemistry

View full text Add to dashboard Cite

Acid‐base homeostasis is an essential process for maintaining proper pH levels in the body, with alterations in this process potentially signaling pathology. While monitoring urine pH, blood gases and other assays can provide information on the overall systemic pH, it is desirable to get more localized knowledge to assist diagnosis. Various non‐invasive methods have been developed with Chemical Exchange Saturation Transfer (CEST) MRI now emerging as a particularly intriguing technology for detecting pH. In this review, we provide an overview of the paramagnetic and diamagnetic CEST probes available for producing pH maps, describe in depth the various methods to collect CEST MRI data and post‐process the resulting images to create pH maps and describe how this has been applied for detecting renal injury, mapping the pH of tumors and monitoring the health of transplanted therapeutic cells. Finally, we will provide an outlook of the possibilities to translate this technology into patients.

show abstract

MRICEST at 1T with large µ_effLn³⁺ complexes T m³⁺‐HPDO3A: An efficient MRI pH reporter

Cited by 19 publications

References 26 publications

Six, Seven or Eight Coordinate Fe^II, Co^II or Ni^II Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry

Six, Seven or Eight Coordinate Fe^II, Co^II or Ni^II Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry

Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI

Contact Info

Product

Resources

About

MRICEST at 1T with large µeffLn3+ complexes T m3+‐HPDO3A: An efficient MRI pH reporter

Cited by 19 publications

References 26 publications

Six, Seven or Eight Coordinate FeII, CoII or NiII Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry

Six, Seven or Eight Coordinate FeII, CoII or NiII Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry

Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI

Contact Info

Product

Resources

About

MRICEST at 1T with large µ_effLn³⁺ complexes T m³⁺‐HPDO3A: An efficient MRI pH reporter

Six, Seven or Eight Coordinate Fe^II, Co^II or Ni^II Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry

Six, Seven or Eight Coordinate Fe^II, Co^II or Ni^II Complexes of Amide‐Appended Tetraazamacrocycles for ParaCEST Thermometry