<scp>N‐acetyl‐b‐D</scp>‐glucosaminidase: A potential cardiorenal biomarker with a relevant impact on <scp>ICD</scp> shock therapies and mortality

Allgaier, Raphael; Strack, Christina; Wallner, Stefan; Hubauer, Ute; Uecer, Ekrem; Lehn, Petra; Keyser, Andreas; Luchner, Andreas; Maier, Lars S.; Jungbauer, Carsten

doi:10.1111/nep.13776

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Furthermore, Peralta CA et al [30] reported a higher concentration of urinary KIM-1 independent of albuminuria, recommending the usage of urinary KIM-1 in the detection of DKD and renal dysfunction even at the early stage when microalbuminuria is not evident. KIM-1 was negatively correlated with eGFR, in line with the study conducted by Allgaier R et al [31] in which there was an inverse relation between eGFR and uKIM-1 values. KIM-1 was also found to be positively associated with HbA1c, urea, BUN, serum creatinine, urine albumin, and UACR.…”

Section: Discussionsupporting

confidence: 91%

Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study

Bano

Imam

Bajpai

et al. 2023

JPM

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The purpose of the study was to examine the urinary levels of kidney injury molecule-1 (KIM-1) and angiopoietin-like protein-4 (ANGPTL-4) in individuals with diabetic kidney disease (DKD) and their association with established DKD diagnostic markers such as albuminuria and estimated glomerular filtration rate (eGFR). Levels of ANGPTL-4 and KIM-1 were estimated in urine samples. A total of 135 participants were recruited into three groups: 45 diabetes type 2 patients in the control group and 90 DKD patients in two disease groups. Concentrations of ANGPTL-4 and KIM-1 were conclusively related to the urinary albumin–creatinine ratio (UACR). Also, the levels of both ANGPTL-4 and KIM-1 were negatively associated with the eGFR. Multivariable Poisson regression analysis showed that urinary ANGPTL-4 (PR: 3.40; 95% CI: 2.32 to 4.98; p < 0.001) and KIM-1 (PR: 1.25; 95% CI: 1.14 to 1.38; p < 0.001) were prevalent in DKD patients. Receiver operating characteristic (ROC) analysis of urinary ANGPTL-4 and KIM-1 in the combined form resulted in an area under curve (AUC) of 0.967 (95%CI: 0.932–1.000; p < 0.0001) in the microalbuminuria group and 1 (95%CI: 1.000–1.000; p < 0.0001) in the macroalbuminuria group. The association of urinary levels of ANGPTL-4 and KIM-1 with UACR and eGFR and significant prevalence in the diabetic kidney disease population illustrates the diagnostic potential of these biomarkers.

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Section: Discussionsupporting

confidence: 91%

Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study

Bano

Imam

Bajpai

et al. 2023

JPM

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Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis

Xu,

Roth,

Heidel

et al. 2024

Biomarkers in Medicine

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Nag: Potential Cardiorenal Biomarker Indicates Progression of Chronic Kidney Disease in Implantable Cardioverter Defibrillator Patients, Contrary to Kim-1

Allgaier¹,

Strack²,

Wallner³

et al. 2022

Biomark. Med.

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Aim: NAG and KIM-1 as markers of tubular damage are suggested as potential biomarkers for the cardiorenal syndrome. Aim of the study was to assess the prognostic capability of NAG and KIM-1 regarding progression of chronic kidney disease (CKD) in patients with implantable cardioverter defibrillator (ICD). Materials & methods: We included 313 patients with an ICD and collected plasma and urine samples. Follow-up was performed after 51 months (interquartile range [IQR]: 25–55). Outcome of interest was continuous CKD progression defined as persistent decline in estimated glomerular filtration rate category accompanied by a ≥25% drop of baseline estimated glomerular filtration rate. Results: Average four (IQR: 2–6) follow-up values of serum creatinine per patient were obtained. During follow-up 29 patients (9%) developed a continuous CKD progression. NAG was shown as independent predictor for continuous CKD progression (p = 0.01), opposite to KIM-1 (p = n.s.). Conclusion: NAG was shown as predictor for a progressive and real deterioration of kidney function in patients with ICD.

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N‐acetyl‐b‐D‐glucosaminidase: A potential cardiorenal biomarker with a relevant impact on ICD shock therapies and mortality

Cited by 3 publications

References 33 publications

Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study

Expression of Angiopoetin-Like Protein-4 and Kidney Injury Molecule-1 as Preliminary Diagnostic Markers for Diabetes-Related Kidney Disease: A Single Center-Based Cross-Sectional Study

Prognostic value of N-Acetylglucosaminidase and Kidney-injury-molecule-1 in TAVI patients with severe aortic stenosis

Nag: Potential Cardiorenal Biomarker Indicates Progression of Chronic Kidney Disease in Implantable Cardioverter Defibrillator Patients, Contrary to Kim-1

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