<scp>NB‐UVB</scp>
            irradiation attenuates inflammatory response in psoriasis

Ye, Jianzhou; Huang, Huei-Jean; Luo, Guangyun; Yin, Lihua; Li, Bocheng; Chen, Sixuan; Li, Hongying; Yang, Yang; Yang, Xuesong

doi:10.1111/dth.13626

Cited by 18 publications

(14 citation statements)

References 25 publications

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“…Prior to testing, the skin type was evaluated based on the Fitzpatrick Skin Type scale. Asian skin type ranges from III‐IV, and therefore participants with Fitzpatrick skin type II – IV were included in the study 20 . Background erythema (T0) was measured in all test areas before treatment using a mexameter probe attached to Cutometer dual MPA 580 (Courage&Khazaka Electronic GmbH).…”

Section: Methodsmentioning

confidence: 99%

Almond consumption increased UVB resistance in healthy Asian women

Li¹,

Henning²,

Thames³

et al. 2021

J of Cosmetic Dermatology

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Background Almonds are a rich source of phenolic and polyphenolic compounds, which have antioxidant activity. In vitro and in vivo studies have demonstrated that topical application of almond oil and almond skin extract reduces UVB‐induced photoaging. Ultraviolet‐B (UVB) protection by oral almond consumption has not been previously studied in humans. Objectives To investigate whether oral almond consumption can increase resistance to UVB radiation and reduce skin aging in healthy Asian women. Methods Thirty‐nine female participants (18‐45 years) with Fitzpatrick skin type II‐IV were randomly assigned to consume either 1.5 oz of almonds or 1.8 oz of pretzels daily for 12 weeks. Minimal erythema dose (MED) was determined using a standardized protocol, which determined the minimal radiation needed to induce erythema on the inner arm following UVB exposure. Facial skin texture was evaluated by two dermatologists using the Clinician's Erythema Assessment scale and Allergan Roughness scale. Facial melanin index, hydration, sebum, and erythema were determined using a cutometer. Results The MED was increased in the subjects consuming almonds compared to the control group consuming pretzels. There were no differences noted between the groups consuming almonds versus pretzels in Allergan roughness, melanin, hydration, or sebum on facial skin. Conclusions Our findings suggest that daily oral almond consumption may lead to enhanced protection from UV photodamage by increasing the MED.

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Section: Methodsmentioning

confidence: 99%

Almond consumption increased UVB resistance in healthy Asian women

Li¹,

Henning²,

Thames³

et al. 2021

J of Cosmetic Dermatology

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“…Psoriasis is a chronic inflammatory disorder that is mainly characterized by vasodilation and immunological imbalance. The activation of NF-κB by some factors results in the initiation of inflammation in psoriasis [206]. The presence of T cells and DCs in the psoriatic lesions enhance the secretion of pro-inflammatory cytokines such as TNFα, IL-1β, IFNγ, IL-17, IL-22, and IL-23 [207].…”

Section: Mn Design For Psoriasis Treatmentmentioning

confidence: 99%

Microneedles for painless transdermal immunotherapeutic applications

Amani

Shahbazi

D'Amico

et al. 2021

Journal of Controlled Release

163

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The mechanisms of its action are unclear but reducing skin mast cell reactivity, degranulating and releasing histamine and other pro-inflammatory mediators are possible modes of action [12,13]. Other plausible mechanisms include apoptosis of dermal mast cells, immunomodulatory action and the production of anti-inflammatory cytokine [14]. The Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI) and the Korean Dermatological Association (KDA) Evidence-Based Practice Guideline suggests that narrowband UVB (NB-UVB) phototherapy can be added to H1-antihistamine treatment for the treatment of chronic spontaneous urticaria (CSU) and symptomatic dermographism [15].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of NB-UVB as Add-on Therapy to Antihistamine in the Treatment of Chronic Urticaria: A Systematic Review and Meta-analysis

Chen

Zeng

Chen

et al. 2021

Dermatol Ther (Heidelb)

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Introduction: Narrow-band ultraviolet B (NB-UVB) phototherapy has been used for the treatment of chronic urticaria (CU), but the clinical efficacy of this treatment modality requires further evidence. A systematic review and meta-analysis of randomized clinical trials were conducted to evaluate the efficacy and safety of NB-UVB as add-on therapy in the treatment of CU. Methods: A literature search was conducted in the Cochrane, Embase, PubMed, Web of Science, CNKI, CBM, VIP and WanFang databases up to October 2020. A total of nine studies involving 713 participants met the inclusion criteria. Results: Two trials showed a significant difference in the Urticaria Activity Score between therapy with NB-UVB ? antihistamines and that with antihistamines alone (mean difference 8.23, 95% confidence interval [CI] 5.78-10.68, p \ 0.00001). Six trials (563 participants) showed a significant benefit of NB-UVB as add-on therapy to antihistamines in the total effective rate (risk ratio [RR] 1.56, 95% CI 1.39-1.75, p \ 0.00001). In terms of adverse events, no statistically significant differences were found for NB-UVB ? antihistamines versus antihistamines alone (RR 1.10, 95% CI 0.67-1.79, p = 0.71). Combination therapy of NB-UVB ? antihistamines yielded a significantly lower risk of recurrence (RR 0.25, 95% CI 0.14-0.44, p \ 0.00001). Conclusion: Our meta-analysis suggests that combination therapy of NB-UVB ? antihistamines is significantly more effective in treating CU than antihistamines alone.

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NB‐UVB irradiation attenuates inflammatory response in psoriasis

Cited by 18 publications

References 25 publications

Almond consumption increased UVB resistance in healthy Asian women

Almond consumption increased UVB resistance in healthy Asian women

Microneedles for painless transdermal immunotherapeutic applications

Efficacy of NB-UVB as Add-on Therapy to Antihistamine in the Treatment of Chronic Urticaria: A Systematic Review and Meta-analysis

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