Palladium‐Catalyzed anti‐Markovnikov Halosulfonamidation of Unactivated Alkene^†

Abstract

Comprehensive SummaryPalladium‐catalyzed regioselective amination of unactivated alkene remains a challenge and is of great interest. Herein, a three‐component coupling of unactivated alkene, sulfonamide and N‐halo compound accessing to vicinal haloamine has been conceived. This aminohalogenation represents a modular and regioselective strategy. The electrophilic halogenating agent enables regioselective anti‐Markovnikov aminopalladation and facilitates subsequent halogenation event. And This protocol is characterized by gram‐scale syntheses and late‐stage functionalizations. Of note, the recovered byproduct phthalimide allows for reusing by conversion to starting material.This article is protected by copyright. All rights reserved.