Palladium‐Catalyzed Carbonylation of Multifunctionalized Substituted Alkynes to Quinolinone Derivatives under Mild Conditions^†

Abstract

Comprehensive SummaryA highly selective palladium‐catalyzed carbonylation of 2‐alkynylanilines bearing an amide moiety to condensed six‐membered heterocyclic structures has been developed under mild conditions (room temperature and atmospheric pressure of CO). This carbonylative protocol is also compatible with CO surrogates, such as triformatebenzene (TFBen) or the newly developed calix[6]arenes functionalized with six formate groups (CLX[6]CO), which are both capable to release CO in situ. A series of tricyclic fused heterocycles containing the important oxazino‐quinolinone scaffold have been selectively obtained (only the 6‐endo‐dig cyclization mode has been observed) in good to excellent yields (up to 99%).This article is protected by copyright. All rights reserved.

A Review of Synthetic Application of Homogeneous, Heterogenised‐Homogeneous, and Microwave‐Assisted Catalytic Carbonylation of Selected Substrates

“…So, Many researchers extensively studied carbonylation processes for heterocycle synthesis [35–40] . Several authors have recently reviewed the cyclo‐carbonylation reaction that gives rise to a simple lactone and lactam ring with five, six, and seven members [41–50] .…”

“…So, Many researchers extensively studied carbonylation processes for heterocycle synthesis. [35][36][37][38][39][40] Several authors have recently reviewed the cyclo-carbonylation reaction that gives rise to a simple lactone and lactam ring with five, six, and seven members. [41][42][43][44][45][46][47][48][49][50] This section explained the synthesis of α, βalkynyl ketones, coumarin, 2-quinolone, indol derivative, furane derivative, and chromenone heterocyclic compound from homogenous palladium-catalyzed carbonylation reaction.…”