<scp>PAS</scp>‐positive extracellular deposits within germinal centers of hyperplastic follicles during <scp>SIV</scp> infection in a rhesus macaque

Hong, Jung Joo; Villinger, François; Courtney, Cynthia L.

doi:10.1111/jmp.12109

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Histologic and cellular characterization of lymph nodes during infection revealed similar structural alterations among SIV-infected rhesus macaques and HIV-infected patients. Although the mechanisms are not fully elucidated yet, gradual histological alterations such as the deposition of collagen and non-amyloid substance may be associated with follicular involution at the end stage of HIV infection (17, 18). Exposure of follicular dendritic cells to HIV may create an inflammatory environment and lead to the impaired survival of follicular B cells (19).…”

Section: Generation Of Follicular Hyperplasia/involutionmentioning

confidence: 99%

The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

2016

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Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment to B cell follicles within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we summarize what is known regarding the kinetics of TFH cells and GC B cells during the course of infection as well as the potential immunopathological features associated with structural changes in the lymphoid compartment. This review also explores the implications of cell dynamics in the formation and maintenance of viral reservoirs in hyperplastic follicles of secondary lymphoid organs before and after viral suppressive antiretroviral therapy.

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Section: Generation Of Follicular Hyperplasia/involutionmentioning

confidence: 99%

The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

2016

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“…Unknown, presumed to represent products of the immune reactions such as antigen-antibody complexes. Increased eosinophilic PAS-positive extracellular germinal center deposits, confirmed by electron microscopy to be non-amyloid, have been associated with follicle involution post-SIV-induced follicular hyperplasia 171 .…”

Section: Hematopoietic and Lymphoid Systemmentioning

confidence: 88%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (<i>M. fascicularis</i>)

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the nonhuman primate used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence

Deléage

Türkbey

Estes

2016

Current Opinion in Virology

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CD4+ T cells are the primary HIV-1 target cell, with the vast majority of these cells residing within lymphoid tissue compartments throughout the body. Predictably, HIV-1 infection, replication, localization, reservoir establishment and persistence, as well as associated host immune and inflammatory responses and disease pathology principally take place within the tissues of the immune system. By virture of the fact that the virus-host struggle is played out within lymphoid and additional tissues compartments in HIV-1 infected individuals it is critical to understand HIV-1 infection and disease within these relevant tissue sites; however, there are obvious limitations to studying these dynamic processes in humans. Nonhuman primate (NHP) research has provided a vital bridge between basic and preclinical research and clinical studies, with experimental SIV infection of NHP models offering unique opportunities to understand key processes of HIV-1 infection and disease that are either not practically feasible or ethical in HIV-1 infected humans. In this review we will discuss current approaches to studying the tissue based immunopathogenesis of AIDS virus infection in NHPs, including both analyses of tissues obtained at biopsy or necropsy and complementary non-invasive imaging approaches that may have practical utility in monitoring HIV-1 disease in the clinical setting.

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PAS‐positive extracellular deposits within germinal centers of hyperplastic follicles during SIV infection in a rhesus macaque

Cited by 4 publications

References 13 publications

The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (<i>M. fascicularis</i>)

Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence

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