2017
DOI: 10.1111/eve.12857
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PCR for antigen receptor rearrangement (PARR) in equine veterinary medicine

Abstract: Summary PCR for antigen receptor rearrangement (PARR) is a technique developed to aid with the assessment of lymphoid malignancies. The technology relies on the assessment of clonality of T or B cells, and there are many pitfalls. One major advantage is that only a small amount of sample is required to detect clonality, and it can be performed on any type of sample, including effusions, formalin‐fixed paraffin‐embedded tissues and cytological samples. However, the risk of both false negative and false positive… Show more

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Cited by 2 publications
(3 citation statements)
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“…The accurate distinction between reactive and neoplastic lymphoid proliferations and the differentiation of T- and B-lymphocytes can be challenging, all the more so since in horses, the most frequent cutaneous malignant lymphomas are T-cell-rich B-cell lymphomas [ 9 , 10 , 20 ]. Molecular clonality assays, assessing clonality of T- or B-cells through PARR can effectively complete clinical, morphologic, and immunophenotypic assessments [ 21 , 22 ]. Clonality assays are species-specific and in veterinary medicine, are currently only available for dogs, cats, and horses [ 21 23 ].…”
Section: Discussionmentioning
confidence: 99%
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“…The accurate distinction between reactive and neoplastic lymphoid proliferations and the differentiation of T- and B-lymphocytes can be challenging, all the more so since in horses, the most frequent cutaneous malignant lymphomas are T-cell-rich B-cell lymphomas [ 9 , 10 , 20 ]. Molecular clonality assays, assessing clonality of T- or B-cells through PARR can effectively complete clinical, morphologic, and immunophenotypic assessments [ 21 , 22 ]. Clonality assays are species-specific and in veterinary medicine, are currently only available for dogs, cats, and horses [ 21 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…Molecular clonality assays, assessing clonality of T- or B-cells through PARR can effectively complete clinical, morphologic, and immunophenotypic assessments [ 21 , 22 ]. Clonality assays are species-specific and in veterinary medicine, are currently only available for dogs, cats, and horses [ 21 23 ]. In the present case, the test was performed using primer sets for equine PARR on formalin-fixed paraffin-embedded tissue.…”
Section: Discussionmentioning
confidence: 99%
“…Sie sollte nicht für sich allein, sondern als zusätzliches Puzzleteil genutzt werden. In der Humanmedizin dient die Untersuchung primär zum Staging und Monitoring [18].…”
Section: Anamneseunclassified