<scp>PET</scp>/<scp>CT</scp> mediastinal and liver <scp>FDG</scp> uptake: Effects of biological and procedural factors

Ashish, Malladi; Maya, Viner; Jackson, Tatianie; Mercier, Gustavo; Subramaniam, Rathan M.

doi:10.1111/1754-9485.12015

Cited by 32 publications

(79 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge, the association between SUVs in liver/mediastinal blood pool and these factors has not yet been investigated in children and adolescents. However, prior research on adult patients have repeatedly shown that bodyweight affects SUVs in both reference regions, e.g., the work by Malladi et al [22] or a study by Groheux et al, who concentrated on the effect of weight on liver only [23]. Malladi et al also found effects of gender on liver and mediastinal blood pool SUV [22], a finding that in our work on paediatric patients could be replicated for liver only.…”

Section: Discussionsupporting

confidence: 68%

What and how should we measure in paediatric oncology FDG-PET/CT? Comparison of commonly used SUV metrics for differentiation between paediatric tumours

et al. 2019

View full text Add to dashboard Cite

Background: In clinical routine, SUV max and SUV peak are most often used to determine the glucose metabolism in tumours by 18 F-FDG PET/CT. Both metrics can be further normalised to SUVs in reference regions resulting in a SUV ratio (SUV ratio ). The aim of the study was to directly compare several widely used SUVs/SUV ratios with regard to differentiation between common tumours in paediatric patients; a special focus was put on characteristics of reference region SUVs.Methods: The final study population consisted of 61 children and adolescents with diagnoses of non-Hodgkin lymphoma (NHL, n = 25), Hodgkin lymphoma (HL, n = 14), and sarcoma (n = 22). SUV metrics included SUV max and SUV peak as well as both parameters normalised to liver and mediastinal blood pool, respectively, yielding the SUV ratios SUV max/liver , SUV max/mediastinum , SUV peak/liver , and SUV peak/mediastinum . Results: The metrics SUV max , SUV peak , SUV max/liver , and SUV peak/liver all proved to be sensitive for tumour differentiation (p ≤ 0.008); in contrast, SUV max/mediastinum and SUV peak/mediastinum revealed to be non-sensitive approaches. Correlation analyses showed inverse associations between reference region SUVs and SUV ratios (p < 0.05). Multiple regression analyses demonstrated significant effects of factors as bodyweight and uptake time on reference region SUVs (p < 0.01), and thus indirectly on the corresponding SUV ratios . Conclusions: In the paediatric population, the ability to differentiate between common tumours remarkably varies between SUV metrics. When using SUV ratios , the choice of reference region is crucial. Factors potentially influencing reference region SUVs (and thus SUV ratios ) should be taken into account in order to avoid erroneous conclusions. When not possible, SUV max and SUV peak represent less complex, more robust alternatives.

show abstract

Section: Discussionsupporting

confidence: 68%

What and how should we measure in paediatric oncology FDG-PET/CT? Comparison of commonly used SUV metrics for differentiation between paediatric tumours

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Numerous authors have used SUV to compare the uptake of 18 F-FDG in lesions with that in normal liver [8][9][10]. However, recent studies have reported that liver 18 F-FDG uptake was vulnerable to variations in age, height, weight, BMI, glucose levels, hepatocellular steatosis, serologic liver enzymes, and serologic lipids [11][12][13][14][15][16][17][18][19][20]. However, recent studies have reported that liver 18 F-FDG uptake was vulnerable to variations in age, height, weight, BMI, glucose levels, hepatocellular steatosis, serologic liver enzymes, and serologic lipids [11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China

Liu

Li²,

Hu³

et al. 2015

Nuclear Medicine Communications

View full text Add to dashboard Cite

BMI, age, triglyceride, HDL, and apolipoprotein-A were independent variables predicting liver (18)F-FDG uptake. Mild and moderate degree of fatty liver had a positive effect on liver (18)F-FDG uptake, whereas a severe degree of fatty liver negatively affected (18)F-FDG uptake. Attention should be paid to liver metabolism in patients with fatty liver before using liver as the comparator in determining focal (18)F-FDG uptake elsewhere within the abdomen.

show abstract

“…The FDG activity in the liver has been used both qualitatively and quantitatively as a standard in PET/CT imaging in oncology[1]. The liver mean Standardized Uptake Value (SUV mean ) normalized to lean body mass (SUL mean ) has been proposed as a quality measure for FDG PET/CT and was used in the PET response criteria in solid tumors (PERCIST) 1.0 [2].…”

Section: Introductionmentioning

confidence: 99%

Liver Standardized Uptake Value Corrected for Lean Body Mass at FDG PET/CT

Chirindel¹,

Alluri²,

Tahari³

et al. 2015

Clinical Nuclear Medicine

View full text Add to dashboard Cite

Objective To establish the magnitude change and inter-reader reliability of Liver SULmean in dual time point imaging at 1 and 2 hours and 1 and 4 hours. Methods Early and Delayed FDG PET/CT scans were included for 28 patients (13 males and 15 females) who had normal liver by CT or US. The average uptake time between the early and delayed scans were 55 minutes (range 44-69) for pancreatic adenocarcinoma patients (n = 19) and 184 minutes (range 140-197) for neurofibromatosis (NF) patients (n = 9). 30-mm- diameter spherical VOI was placed within the right lobe of the liver above, below, and at the level of the main portal vein by two independent readers. Correlation coefficients, Analysis of variance, intraclass correlation coefficient (ICC), and Bland-Altman analysis were performed. Results The mean liver SULmean was between 1.39 and 1.42 and between 1.28 and 1.3 in early and delayed images, respectively (p = 0.001). There is time dependent reduction in the mean Liver SULmean at 2 hour (7-8%) and four hour uptake time (15-21%), compared to one hour. The correlation coefficient between delayed uptake time and Liver SULmean reduction is 0.39 to 0.41 at the upper aspect of liver. The ICC for two readers varied between 0.997 and 0.998 and between 0.995 and 0.999 in early and delayed images, respectively (p=0.001). Conclusion There is time dependent reduction of mean Liver SULmean, about 7-8% within the clinically relevant FDG uptake time, in the same patient with excellent inter-reader agreement in early and delayed images within the right lobe of the liver. Therefore Liver SULmean could represent a useful reference parameter in quantitative analysis of dual-phase FDG PET/CT in malignancy or atypical infection/inflammatory disease. Furthermore, it may be suitable as normalization factor in currently available formulae quantifying therapy response on PET imaging.

show abstract

PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors

Abstract: BMI has the highest effect and correlation on mediastinal and liver FDG uptake. FDG uptake time has a greater effect on mediastinal than liver SUVlbm mean.

Cited by 32 publications

References 23 publications

What and how should we measure in paediatric oncology FDG-PET/CT? Comparison of commonly used SUV metrics for differentiation between paediatric tumours

What and how should we measure in paediatric oncology FDG-PET/CT? Comparison of commonly used SUV metrics for differentiation between paediatric tumours

The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China

Liver Standardized Uptake Value Corrected for Lean Body Mass at FDG PET/CT

Contact Info

Product

Resources

About